| Simvastatin plus ezetimibe (n = 4650) | Placebo (n = 4620) |
---|---|---|
Demographics | ||
 Age at randomization (years)a | 62 (12) | 62 (12) |
 Men | 2915 (63%) | 2885 (62%) |
 Ethnicity | ||
  White | 3332 (72%) | 3314 (72%) |
  Black | 137 (3%) | 127 (3%) |
  Chinese | 557 (12%) | 563 (12%) |
  Other Asian | 486 (10%) | 480 (10%) |
  Other/not specified | 138 (3%) | 136 (3%) |
Prior disease | ||
 Prior vascular diseasea | 711 (15%) | 682 (15%) |
 Diabetesa | 1054 (23%) | 1040 (23%) |
 Renal status | ||
  On dialysisa | 1534 (33%) | 1491 (32%) |
   Haemodialysis | 1275 (27%) | 1253 (27%) |
   Peritoneal dialysis | 259 (6%) | 238 (5%) |
  Not on dialysisa | 3116 (67%) | 3129 (68%) |
Baseline measurements | ||
 Total cholesterol (mmol/L)a | 4.88 (1.20) | 4.90 (1.17) |
 LDL cholesterol (mmol/L)a | 2.77 (0.88) | 2.78 (0.87) |
 HDL cholesterol (mmol/L)a | 1.12 (0.35) | 1.11 (0.34) |
 Triglycerides (mmol/L)a | 2.31 (1.76) | 2.34 (1.68) |
 Body mass index (kg/m2)a | 27.1 (5.7) | 27.1 (5.6) |
Renal function | ||
 MDRD-estimated GFR (mL/min/1.73 m2)a,b,c | 26.6 (12.9) | 26.6 (13.1) |
  ≥60 | 44 (1%) | 44 (1%) |
  ≥30 to <60 | 1100 (37%) | 1055 (35%) |
  ≥15 to <30 | 1246 (41%) | 1319 (44%) |
   < 15 | 613 (20%) | 606 (20%) |
  Not available | 113 | 105 |