Fig. 1From: Citrate shows protective effects on cardiovascular and renal function in ischemia-induced acute kidney injuryExperimental design. Infusions through each catheter during each experimental period are indicated. Both renal pedicles were atraumatically clamped during the 40Â min ischemic period. In the initial study, the dose of trisodium citrate administered pre-ischemia for 60Â min and during the first 45Â min of reperfusion was 0.3, 0.6 or 1.0Â mmol/kg/h at a rate of 5Â ml/kg/h. In the normoxic and I/R control groups, 0.9% NaCl solution was infused instead at the same rates. In a follow-up study, 1.0Â mmol/kg/h trisodium citrate was compared to 3.0Â mmol/kg/h NaCl delivered as a 3.5% solution. Calcium gluconate solutions were administered at 2Â ml/kg/h. [cross black], blood sampling, [cross white], urine sampling. Blood pressure, heart rate, respiratory rate, core body temperature, and peripheral oxygen saturation were continuously monitored during the entire experimentBack to article page