Citrate shows protective effects on cardiovascular and renal function in ischemia-induced acute kidney injury

BMC Nephrology

Table 1 Measurements of blood and plasma parameters

		Normoxic control group	I/R control group	0.3 mmol/kg/h citrate group	0.6 mmol/kg/h citrate group	1.0 mmol/kg/h citrate group
	Baseline Values			End Values
pH	7.36 + 0.02	7.36 + 0.03	7.31 + 0.02	7.28 + 0.01##	7.31 + 0.01	7.27 + 0.02##
Base excess [mmol/l]	−0.0 + 0.5	−1.0 + 0.3	−4.8 + 0.5###	−4.2 + 1.0##	−3.8 + 0.9##	−5.4 + 0.5###
pCO₂ [mmHg]	45.2 + 1.8	43.9 + 3.9	42.0 + 2.2	47.3 + 2.4	43.9 + 2.2	46.2 + 3.4
pO₂ [mmHg]	437.5 + 12.7	446.7 + 10.0	452.2 + 12.8	444.7 + 11.5	439.3 + 5.9	437.2 + 12.0
K⁺ [mmol/l]	5.1 + 0.1	4.4 + 0.1	6.1 + 0.1###	6.4 + 0.1###	6.0 + 0.1###	5.8 + 0.1###
Cl^-[mmol/l]	111 + 1	114 + 1	115 + 1	113 + 2	112 + 2	110 + 1**
Na⁺ [mmol/l]	139 + 1	141 + 1	140 + 1	139 + 1	141 + 0	143 + 1**
Glucose [mg/dl]	172 + 14	136 + 5	150 + 6	162 + 26	135 + 9	126 + 12
Lactate [mmol/l]	0.97 + 0.13	0.72 + 0.05	0.68 + 0.07	0.63 + 0.05	0.65 + 0.03	0.62 + 0.08

Values are means ± SE; n = 6 per group. Baseline values were obtained from the normoxic control group after the acclimation period; these values were not significantly different from the baseline values of the other experimental groups. The other values were assessed from the last blood sampling at the end of the full ischemia/reperfusion period. For experimental details, see Fig. 1
## p < 0.01 and ### p < 0.001 vs. normoxic control group. ** p < 0.01 vs. I/R control group

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