Characteristics | Model from primary analysisa Odds ratio (95% confidence interval) | P valuec (PT) | Sensitivity analysis Odds ratiob (95% confidence interval) | P valuec (PT) | |
---|---|---|---|---|---|
Females |  | 0.64 (0.49–0.83) | 0.0008 | 0.64 (0.51–0.82) | 0.0003 |
Age categories (years) | 65–69 | 0.83 (0.52–1.35) | 0.55 | 0.85 (0.55–1.31) | 0.64 |
70–74 | 0.70 (0.46–1.09) |  | 0.75 (0.51–1.12) |  | |
75–79 | 0.78 (0.54–1.13) |  | 0.82 (0.58–1.15) |  | |
80–84 | 0.84 (0.59–1.18) |  | 0.93 (0.68–1.26) |  | |
≥85 | 1 |  | 1 |  | |
Smoking status | Non-smoker | 1 | Â | Not in model | Â |
Current smoker | 1.39 (0.92–2.11) | 0.25 |  |  | |
Ex-smoker | 1.26 (0.91–1.74) |  |  |  | |
Alcohol intake (units/day) | Non-drinker | 1 | Â | Not in model | Â |
Ex-drinker | 1.00 (0.64–1.55) | 0.43 |  |  | |
Current ≤6 units/day | 0.88 (0.61–1.26) |  |  |  | |
Heavy >6 units/day | 0.55 (0.24–1.26) |  |  |  | |
BMI (kg/m2) | 15–18.4 | 0.95 (0.45–2.00) | 0.53 | Not in model |  |
18.5–24.9 | 1 |  |  |  | |
25–29.9 | 0.90 (0.65–1.23) |  |  |  | |
≥30 | 1.14 (0.82–1.58) |  |  |  | |
eGFR (mL/min/1.73m2): | ≤29 | 4.62 (3.06–6.99) | <0.0001 | 4.43 (3.03–6.46) | <0.0001 |
30–59 | 2.48 (1.84–3.33) | (<0.0001) | 2.21 (1.68–2.90) | (<0.0001) | |
≥60 | 1 |  | 1 |  | |
Proteinuria |  | 1.23 (0.95–1.59) | 0.12 | 1.22 (0.96–1.56) | 0.10 |
Hypertension |  | 1.27 (0.93–1.73) | 0.13 | 1.17 (0.89–1.55) | 0.26 |
Congestive cardiac failure |  | 1.03 (0.76–1.39) | 0.86 | 0.97 (0.73–1.29) | 0.83 |
Ischaemic heart disease |  | 0.76 (0.58–1.00) | 0.04 | 0.77 (0.60–0.98) | 0.03 |
Cerebrovascular diseases |  | 0.90 (0.68–1.20) | 0.47 | 0.96 (0.74–1.24) | 0.74 |
Dementia |  | 1.17 (0.73–1.88) | 0.53 | 1.10 (0.73–1.67) | 0.65 |
Chronic lung disease |  | 0.79 (0.58–1.07) | 0.12 | 0.90 (0.68–1.18) | 0.43 |
Cancer |  | 0.76 (0.54–1.07) | 0.11 | 0.73 (0.53–1.01) | 0.05 |
Connective tissue diseases |  | 0.66 (0.40–1.08) | 0.08 | 0.68 (0.43–1.07) | 0.08 |
Either ACEI/ARBs |  | 1.59 (1.19–2.13) | 0.002 | 1.66 (1.27–2.17) | 0.0001 |
HBA1C levels | Good <7% | 1 | Â | Not in model | Â |
Borderline 7–10% | 0.82 (0.62–1.09) | 0.38 |  |  | |
High >7% | 0.82 (0.43–1.54) |  |  |  | |
Medication diabetes | None | 1 | Â | 1 | Â |
Oral | 1.05 (0.75–1.46) | 0.05 | 1.00 (0.74–1.33) | 0.08 | |
Insulin | 2.27 (1.27–4.05) |  | 1.89 (1.14–3.11) |  | |
Both | 1.11 (0.72–1.71) |  | 1.03 (0.72–1.47) |  | |
Study period | April 2004–September 2007 | 1 | <0.0001 | 1 | <0.0001 |
October 2007–March 2011 | 2.90 (2.14–3.95) | (<0.0001) | 2.94 (2.22–3.89) | (<0.0001) |