Vitamin D receptor activation reduces inflammatory cytokines and plasma MicroRNAs in moderate chronic kidney disease – a randomized trial

Table 2 The concentration of cytokines (pg/ml) in plasma, pre- and post-treatment within each group; placebo, 1 μg and 2 μg paricalcitol

Cytokine	Placebo Pre / Post	p-value	Paricalcitol 1 μg Pre / Post	p-value	Paricalcitol 2 μg Pre / Post	p-value
VEGF^a	20 (9–36) / 18 (13–21)	0.2	20 (15–31) / 10 (3–15)	0.01	26 (9–60) / 10 (7–32)	0.02
PDGF^b	1220 (719–3740) / 837 (411–3084)	0.2	1297 (960–1933) / 784 (561–915)	0.005	2811 (1447–3706) / 1234 (1003–2239)	0.009
IP-10^c	342 (169–5167) / 332 (71–5091)	0.8	423 (353–2805) / 402 (274–614)	0.08	2628 (511–6200) / 492.5 (270–2022)	0.02

Values are given as median and interquartile range (25–75%). The analysis was done by nonparametric Wilcoxon matched-pairs signed rank test
The significant p-values are presented in bold
^aVascular endothelial growth factor
^bPlatelet-derived growth factor
^cInterferon gamma-induced protein-10

ISSN: 1471-2369