Severe impairment (<30 ml/min) | P value* | Mild/moderate impairment (30–80 ml/min) | P value* | Normal renal (>80 ml/min) | P value* | ||||
---|---|---|---|---|---|---|---|---|---|
LZD (N = 9) | VAN (N = 16) | LZD (N = 73) | VAN (N = 79) | LZD (N = 127) | VAN (N = 101) | ||||
Age (yr); mean (SD) | 77 (10) | 76 (14) | 0.90 | 72 (13) | 72 (10) | 0.98 | 55 (18) | 51 (17) | 0.11 |
Male gender; n (%) | 3 (33) | 7 (44) | 0.69 | 44 (60) | 51 (65) | 0.62 | 90 (71) | 68 (67) | 0.57 |
Weight (kg); mean (SD) | 64 (12) | 72 (24) | 0.40 | 72 (18) | 71 (18) | 0.87 | 83 (25) | 83 (22) | 0.94 |
Race; n (%) | |||||||||
White | 9 (100) | 8 (50) | 0.04 | 52 (71) | 50 (63) | 0.27 | 83 (65) | 76 (75) | 0.08 |
Black | 0 | 3 (19) | 6 (8) | 11 (14) | 18 (14) | 15 (15) | |||
Asian | 0 | 5 (31) | 10 (14) | 16 (20) | 20 (16) | 5 (5) | |||
Other | 0 | 0 | 5 (7) | 2 (3) | 6 (5) | 5 (5) | |||
CLcr; mean (SD) | 22 (6) | 22 (6) | 0.98 | 58 (14) | 59 (14) | 0.51 | 139 (56) | 154 (66) | 0.08 |
Apache II score; n/mean (SD) | 9/21 (7) | 16/20 (7) | 0.80 | 71/19 (6) | 75/18 (6) | 0.60 | 125/16 (6) | 101/16 (5) | 0.98 |
Bacteremia; n (%) | 0 | 2 (13) | 0.52 | 15 (21) | 17 (22) | 1.0 | 10 (8) | 13 (13) | 0.27 |
Ventilated at baseline; n (%) | 7 (78) | 11 (69) | 1.0 | 45 (62) | 51 (65) | 0.74 | 91 (72) | 77 (76) | 0.45 |
ICU at baseline; n (%) | 7 (78) | 13 (81) | 1.0 | 59 (81) | 67 (85) | 0.53 | 106 (84) | 90 (89) | 0.25 |
MIC (μg/ml); n (%) | |||||||||
0.5 | 2 (22) | 0 | 0.05 | 3 (4) | 2 (3) | 0.73 | 11(9) | 12 (12) | 0.33 |
1 | 5 (56) | 15 (94) | 55 (75) | 59 (75) | 98 (77) | 69 (68) | |||
≥ 2 | 2 (22) | 1 (6) | 5 (7) | 9 (11) | 5 (4) | 9 (9) | |||
unknown | 0 | 0 | 10 (14) | 9 (11) | 13 (10) | 11 (11) | |||
Treatment duration (days); mean (SD) | 11 (5) | 10 (5) | 0.60 | 9 (4) | 10 (4) | 0.69 | 10 (4) | 10 (4) | 0.57 |