Clinical outcomes of linezolid and vancomycin in patients with nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus stratified by baseline renal function: a retrospective, cohort analysis

Table 4 Vancomycin parameter estimates from the population PK model

Parameter	Typical Value (%RSE^a)	Inter-individual Variability %CV (%RSE^a)
CL (L/h/80 ml/min), θ_CL	3.12 (6.1)	47.5 (13.2)
V₁ (L/70 kg), θ_V1	43.5 (22.8)	92.2 (40.4)
Q (L/h), θ_Q	8.66 (51.6)	NE
V₂ (L/70 kg), θ_V2	45.8 (19.1)	81.5 (30.1)
Residual Error Parameter
σ² _1prop (%)	23.2 (15.6)

CLclearance, V ₁central volume of distribution, Q inter-compartmental clearance, V ₂peripheral volume of distribution, σ ² _1prop proportional component of the residual error model, NE not estimated
^a%RSE: percent relative standard error of the estimate = SE/parameter estimate * 100 (for variability terms this is the %RSE of the variance estimate)

ISSN: 1471-2369