Table 5 Summary of vancomycin dose, estimated PK and PK-PD index parameters by baseline renal function
Parametersa | Normal renal (>80 ml/min) (n = 67) | Mild/moderate impairment (30–80 ml/min) (n = 53) | Severe impairment (<30 ml/min) (n = 13) | |
|---|---|---|---|---|
Daily dose (mg/kg/day) | Mean (CV%) | 29.4 (36) | 23.2 (39) | 13.5 (58) |
Median (range) | 28.6 (9.3–60.4) | 23.5 (8.2–53.0) | 11.6 (4.0–35.3) | |
Clearance (CL, l/h) | Mean (CV%) | 5.7 (44) | 2.7 (38) | 1.0 (47) |
Median (range) | 5.3 (0.8–11.3) | 2.8 (0.9–4.9) | 0.9 (0.3–2.0) | |
AUC0–24 (μg·h/ml) | Mean (CV%) | 428 (38) | 524 (33) | 548 (22) |
Median (range) | 404 (153–1121) | 484 (226–1203) | 516 (384–777) | |
AUC0–24/MIC | Mean (CV%) | 458 (58) | 490 (41) | 524 (26) |
Median (range) | 394 (76–1320) | 472 (108–1203) | 514 (309–777) | |
Trough concentration (Cmin, μg/ml) | Mean (CV%) | 11.9 (54) | 16.0 (40) | 18.4 (25) |
Median (range) | 10.6 (3.2–38.6) | 15.0 (6.7–42.5) | 18.0 (12.4–28.7) |