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Table 4 Renal hemodynamics and metabolism over time in the two groups of animals

From: The effects of acute renal denervation on kidney perfusion and metabolism in experimental septic shock

 

T-1

T0

T3

T6

T9

T12

T15

T18

RBF, mL/min

 Control

194 ± 48

157 ± 24*

121 ± 36*

116 ± 62*

84 ± 61*

44 ± 28*

37 ± 30*

31 ± 29*

 Denervation

163 ± 69

237 ± 59*,#

213 ± 50*,#

186 ± 36#

109 ± 64

64 ± 42*

43 ± 39*

38 ± 35*

RBF/CO, %

 Control

4.8 ± 0.2

4.1 ± 33

2.9 ± 0.8*

2.6 ± 0.9*

1.8 ± 0.1*

1.2 ± 0.5*

0.9 ± 0.5*

0.8 ± 0.7*

 Denervation

4.5 ± 0.2

4.9 ± 9

5.0 ± 1.5#

4.1 ± 0.9#

2.8 ± 1.7

1.9 ± 0.8*

1.2 ± 0.9*

1.3 ± 0.1*

Renal DO2I, mL/min/m2

 Control

-

14.3 ± 4

12.2 ± 4.1

11.6 ± 6.7

8.2 ± 6.8

4.1 ± 2.9*

4.0 ± 2.4*

2.7 ± 1.8*

 Denervation

-

21.6 ± 3

21.1 ± 7.8#

17.8 ± 5.3

10.9 ± 5.7*

6.3 ± 4.0*

4.2 ± 3.8*

3.5 ± 3.4*

Renal VO2I, mL/min/m2

 Control

-

2.0 ± 1.0

1.7 ± 0.6

1.3 ± 0.5

1.1 ± 0.5*

0.9 ± 0.5*

0.9 ± 0.2*

0.9 ± 0.3*

 Denervation

-

1.9 ± 0.8

1.9 ± 0.5

1.4 ± 0.4

1.0 ± 0.4*

1.2 ± 0.6

0.6 ± 0.3*

0.7 ± 0.6*

Renal O2ER, %

 Control

-

14 ± 4

15 ± 5

13 ± 5

20 ± 11

32 ± 19

33 ± 21

45 ± 23

 Denervation

-

10 ± 6

10 ± 3

8 ± 3

11 ± 6

21 ± 10

32 ± 24

31 ± 16

Laser Dopplercortex, BPU

 Control

-

42 ± 9

46 ± 7

43 ± 14

42 ± 26

26 ± 19*

19 ± 15*

14 ± 13*

 Denervation

-

59 ± 10#

60 ± 11#

59 ± 14#

47 ± 21

35 ± 25

28 ± 26*

26 ± 17

Laser Dopplermedulla, BPU

 Control

-

18 ± 7

20 ± 11.0

21 ± 11

19 ± 10

16 ± 12

11 ± 9*

10 ± 9*

 Denervation

-

19 ± 11

20 ± 10

23 ± 12

17 ± 14

12 ± 8

7 ± 6*

9 ± 8*

Lactatecortex, mmol/L

 Control

-

0.5 ± 0.3

0.8 ± 0.3*

0.7 ± 0.3

0.9 ± 0.4*

1.5 ± 0.7*

2.6 ± 0.9*

4.5 ± 1.2*

 Denervation

-

0.7 ± 0.2

0.9 ± 0.4

0.9 ± 0.3

0.9 ± 0.3

1.3 ± 0.6

1.6 ± 0.4*,#

2.5 ± 0.8*,#

ΔLactatecortex, mmol/L

 Control

-

−0.3 ± 0.3

−0.3 ± 0.3

−0.5 ± 0.3

−1.0 ± 0.6*

−2.1 ± 1.6*

−3.8 ± 3.1*

−6.6 ± 3.3*

 Denervation

-

−0.8 ± 0.3

−0.3 ± 0.5

−0.5 ± 0.5

−1.3 ± 0.7

−1.4 ± 1.1

−2.8 ± 1.5*

−5.6 ± 3.4*

Pyruvatecortex, mmol/L

 Control

-

27 ± 11

41 ± 23*

42 ± 13*

62 ± 26*

75 ± 29*

76 ± 49*

66 ± 46.0

 Denervation

-

30 ± 6

36 ± 10

32 ± 6

35 ± 11#

41 ± 23#

35 ± 22

22 ± 17#

ΔPyruvatecortex, mmol/L

 Control

-

−10 ± 10

−17 ± 10

−27 ± 21*

−41 ± 13*

−91 ± 38*

−150 ± 51*

−150 ± 51*

 Denervation

-

−26 ± 21

−18 ± 11

−50 ± 17*,#

−67 ± 16*,#

−82 ± 27*

−115 ± 22*

−200 ± 32*,#

LPRcortex, mmol/L

 Control

-

19.3 ± 6

21.9 ± 6.7

17.5 ± 8.3

17 ± 6.8

22.7 ± 161.1

51.2 ± 43.7

137.7 ± 126.2

 Denervation

-

26.3 ± 5.7

25.7 ± 6.2

29.2 ± 9.8

28.5 ± 12.5

43 ± 36.4

74.8 ± 52.9*

177.9 ± 106.3*

Glucosecortex, mg/dL

 Control

-

21 ± 8

18 ± 7

22 ± 12

25 ± 9

22 ± 13

21 ± 15

18 ± 17

 Denervation

-

26 ± 5

25 ± 7

25 ± 6

23 ± 8

25 ± 10

22 ± 13

12 ± 11*

  1. RBF renal blood flow, RBF/CO relative renal blood flow, DO 2 I oxygen delivery index, VO 2 I oxygen consumption index, O 2 ER oxygen extraction ratio, ΔLactate cortex plasma to cortical lactate gradient, ΔPyruvate cortex plasma to cortical pyruvate gradient, LPR cortex cortical lactate/pyruvate ratio
  2. *p < 0.05 vs. baseline, # p < 0.05 vs. control
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BMC Nephrology

ISSN: 1471-2369

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