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Table 5 Stratified analysis by follow-up time period for mortality for patients who experienced peritonitis in the COX proportional hazards regression models

From: The impact of peritoneal dialysis-related peritonitis on mortality in peritoneal dialysis patients

Time period (years) No. of patients No. of deaths Univariate model Multivariate model#
HR (95% CI) P value HR (95% CI) P value
All-cause mortalitya
 Overall 1321 261 2.19 (1.68–2.85) <0.001 1.95 (1.46–2.60) <0.001
 ≤2 years 1321 131 1.19 (0.75–1.88) 0.465 0.80 (0.46–1.38) 0.421
 >2 years 939 130 4.65 (3.26–6.63) <0.001 3.98 (2.70–5.86) <0.001
Infection-related mortalityb
 Overall 1321 46 6.00 (3.26–11.03) <0.001 4.94 (2.47–9.86) <0.001
 ≤2 years 1321 16 2.25 (0.79–6.43) 0.129 1.06 (0.26–4.32) 0.932
 >2 years 939 30 12.47 (5.18–30.01) <0.001 9.33 (3.56–24.47) <0.001
CV mortalityc      
 Overall 1321 147 2.05 (1.43–2.93) <0.001 1.90 (1.28–2.81) 0.001
 ≤2 years 1321 75 1.05 (0.55–1.99) 0.882 0.69 (0.32–1.48) 0.339
 >2 years 939 72 4.51 (2.80–7.27) <0.001 4.13 (2.46–6.94) <0.001
  1. Note: Peritonitis was parameterized as a time-dependent covariate
  2. #Multivariable models were adjusted for age, sex, diabetes, history of CVD, 24-h urine output, hemoglobin, serum phosphorus, and serum albumin.
  3. aOverall test for interaction of peritonitis and time period, Wald 2 = 8.23, P = 0.004; all-cause mortality.
  4. bOverall test for interaction of peritonitis and time period, Wald2 = 6.02, P = 0.014; infection-related mortality.
  5. cOverall test for interaction of peritonitis and time period, Wald2 = 2.32, P = 0.128; CV mortality