The impact of peritoneal dialysis-related peritonitis on mortality in peritoneal dialysis patients

BMC Nephrology

Table 5 Stratified analysis by follow-up time period for mortality for patients who experienced peritonitis in the COX proportional hazards regression models

Time period (years)	No. of patients	No. of deaths	Univariate model		Multivariate model^#
Time period (years)	No. of patients	No. of deaths	HR (95% CI)	P value	HR (95% CI)	P value
All-cause mortality^a
Overall	1321	261	2.19 (1.68–2.85)	<0.001	1.95 (1.46–2.60)	<0.001
≤2 years	1321	131	1.19 (0.75–1.88)	0.465	0.80 (0.46–1.38)	0.421
>2 years	939	130	4.65 (3.26–6.63)	<0.001	3.98 (2.70–5.86)	<0.001
Infection-related mortality^b
Overall	1321	46	6.00 (3.26–11.03)	<0.001	4.94 (2.47–9.86)	<0.001
≤2 years	1321	16	2.25 (0.79–6.43)	0.129	1.06 (0.26–4.32)	0.932
>2 years	939	30	12.47 (5.18–30.01)	<0.001	9.33 (3.56–24.47)	<0.001
CV mortality^c
Overall	1321	147	2.05 (1.43–2.93)	<0.001	1.90 (1.28–2.81)	0.001
≤2 years	1321	75	1.05 (0.55–1.99)	0.882	0.69 (0.32–1.48)	0.339
>2 years	939	72	4.51 (2.80–7.27)	<0.001	4.13 (2.46–6.94)	<0.001

Note: Peritonitis was parameterized as a time-dependent covariate
^#Multivariable models were adjusted for age, sex, diabetes, history of CVD, 24-h urine output, hemoglobin, serum phosphorus, and serum albumin.
^aOverall test for interaction of peritonitis and time period, Wald ² = 8.23, P = 0.004; all-cause mortality.
^bOverall test for interaction of peritonitis and time period, Wald² = 6.02, P = 0.014; infection-related mortality.
^cOverall test for interaction of peritonitis and time period, Wald² = 2.32, P = 0.128; CV mortality

ISSN: 1471-2369