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Table 1 Characteristics of studies included in the systematic review

From: Safety of low-molecular-weight heparin compared to unfractionated heparin in hemodialysis: a systematic review and meta-analysis

Study Year Country Follow-up Patients enrolled (n)
LMWH/UFH (n/n)
Drop-outs (n)
LMWH/UFH (n/n)
LMWH type LMWH mean dose UFH mean dose HD/HDF
Cross-over randomized design
 Cianciolo et al. [16] 2011 Italy 2 months 40 0 Nadroparin 64 IU/kg bolus 50 IU/kg and 30 IU/kg/h HD
 Klejna et al. [29] 2014 Poland 6 months 21 0 Enoxaparin 5280 IU ± 1120 IU 4881 IU ± 1916.3 IU HD
 Lord et al. [22] 2002 Canada 2 months 32 2 Tinzaparin 4318.2 IU ± 702.8 IU 8207.9 IU ± 2530.9 IU HD
 Saltissi et al. [24] 1999 Australia 6 months 36 5 Enoxaparin 100 IU/kg bolus 50 IU/kg and 1000 IU/h HD
 Stefoni et al. [27] 2002 Italy 36 months 54 7 Nadroparin 64 IU/kg bolus 1500 IU and 1500 IU and 1500 IU ± 500 IU perfusion HDF
Cross-over non-randomized design
 Al-Saran et al. [13] 2010 Saudi Arabia 12 months 23 0 Tinzaparin 2000–3000 IU 5000 IU HD
 Bambauer et al. [14] 1990 Germany 12 months 27 6 Dalteparin 4216 IU ± 2237 IU 4958 IU ± 2561 IU HD
 Bramham et al. [15] 2008 United Kingdom 4 months 110 2 Tinzaparin 2500–5000 IU 1000 IU ± 500–2000 IU HDF
 Deuber et al.
 (part 1) [17]
1991 Germany 60 months 5 0 Non specified Non specified 29–143 IU/kg HD
 Deuber et al.
 (part 2) [17]
1991 Germany 24 months 5 0 Non specified Non specified 29–143 IU/kg HD
 Kronenberg et al. [19] 1995 Austria 12 months 24 0 Certoparin 44.7 IU/kg ± 21.5 IU/kg 25.1 IU/kg ± 7.8 IU/kg HD
 Lai et al. [20] 2001 China 24 months 40 6 Nadroparin 4100–6150 IU 5000–7000 IU HD
 Leu et al. [21] 1998 Taiwan 4 months 20 0 Dalteparin 2413 IU ± 954 IU 2413 IU ± 954 IU HD
 Schmitt et al. [25] 1993 Germany 12 months 22 0 Dalteparin bolus 1500 IU and 675 IU/h ± 284 IU/h bolus 1500 IU and 1031 IU/h ± 342 IU/h HD
 Yang et al.
 (part 1) [28]
1998 Taiwan 1 month 10 0 Fraxiparin 10,000 ICU bolus 1800 IU ± 675 IU and 895 IU/h ± 340 IU/h HD
 Yang et al.
 (part 2) [28]
1998 Taiwan 12 months 10 2 Fraxiparin 192.9 ICU/kg ± 3.8 ICU/kg bolus 1800 IU ± 675 IU and 895 IU/h ± 340 IU/h HD
Randomized parallel design
 Elisaf et al. [18] 1997 Greece 12 months 76
38/38
0 Tinzaparin 3000 IU 5000–7000 IU HD
 Nurmohamed et al. [23] 1991 The Netherlands 6 months 70
35/35
13
8/5
Nadroparin 150–200 IU/kg bolus 2500 IU and 600–2200 IU/h HD
 Schrader et al. [26] 1988 Germany 12 months 70
35/35
8
5/3
Dalteparin bolus 36.8 IU/kg ± 17.3 IU/kg and 12.2 IU/kg/h ± 5.0 IU/kg/h bolus 58.3 IU/kg ± 26.3 IU/kg and 16.6 IU/kg/h ± 6.7 IU/kg/h HDF
  1. HD Hemodialysis, HDF Hemodiafiltration