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Table 3 Bleeding events and relative risk with 95% CI for LMWH compared to UFH

From: Safety of low-molecular-weight heparin compared to unfractionated heparin in hemodialysis: a systematic review and meta-analysis

Study, year Total bleeding events LMWH (n/N) Total bleeding events UFH (n/N) RR (95% CI) Comments
Al-Saran et al. 3/23 0/23 7.00 (0.38–128.33) 3 minor bleedings with LMWH, controlled with dose adjustment
Bambauer et al. 3/27 6/27 0.50 (0.14–1.80) No indication if minor or major bleeding events
Bramham et al. 0/110 4/110 0.11 (0.01–2.04) 4 minor bleeding episodes with UFH
Lord et al. 3/32 8/32 0.38 (0.11–1.29) LMWH: 1 major and 2 minor bleedings; UFH: 8 minor bleedings
Nurmohamed et al. 3/35 0/35 7.00 (0.37–130.69) 3 minor bleeding events with LMWH
Saltissi et al.a 12/36 6/36 2.00 (0.84–4.75) LMWH:1 major and 11 minor bleedings; UFH: 6 minor bleedings
Stefoni et al. 0/54 7/54 0.07 (0.00–1.14) 7 minor bleeding events with UFH
Schrader et al.b 0/35 0/35 excluded n/a
Yang et al. (part 1)b 0/10 0/10 excluded n/a
Summary 24/362 31/362 0.76 (0.26–2.22)  
  1. aDetails of bleeding events extracted from Lim et al.
  2. bStudies excluded due to “zero cells” in both LMWH and UFH groups