Metabolic syndrome is independently associated with a mildly reduced estimated glomerular filtration rate: a cross-sectional study

Table 2 Multiple linear regression analysis of the relationship between MS components and eGFR

Models Independent variable	Unadjusted		Multivariable adjusted^a
Models Independent variable	b Coefficient (95% CI)	P-value	b Coefficient (95% CI)	P-value
1 MS Model
MS Y/N	-2.494 (−3.364 to −1.624)	<0.001	−1.329 (−2.098 to −0.520)	0.002
2 MS components Model
SBP, per mmHg	0.003 (−0.013 to 0.019)	0.753	0.008 (−0.00 7to 0.022)	0.246
DBP, per mmHg	−0.008 (−0.028 to 0.012)	0.420	−0.012 (−0.029 to 0.005)	0.158
TG, per mmol/L	−1.082 (−1.414 to −0.750)	<0.001	−1.225 (−1.518 to −0.931)	<0.001
HDL, per mmol/L	0.360 (−0.444 to 1.165)	0.380	0.418 (−0.294 to 1.130)	0.250
Waist circumference, per cm	−0.310 (−0.369 to −0.252)	<0.001	−0.075 (−0.126 to −0.024)	0.004
BMI, per kg/m2	0.293 (0.128–0.458)	0.001	−0.043 (−0.195 to 0.109)	0.580
FPG, per mg/dL	0.443 (0.173–1.714)	0.001	0.740 (0.500–0.980)	0.024
3 MS components + HbA1C Model
HbA1c, per % unit	0.978 (0.593–1.363)	<0.001	1.254 (0.850–1.657)	<0.001

CI confidence interval, MS Metabolic syndrome, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HDL high density lipoprotein, FPG fasting plasma glucose, TG Triglycerides, e-GFR estimated glomerular filtration rate. HbA1c Glycosylated hemoglobin A1c; ^aAdjusting for age and gender, current smoking, history of hypertension, drinking, use of ACE inhibitors or ARB, control of diabetes and hypertension

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