Table 3 Univariate and multiple binary logistic regression models investigating the robustness of baseline blood miR-3907 as a predictor of GFR loss during 12 months of follow-up in 80 ADPKD patients. A decrease of >10% of baseline eGFR at follow-up was defined as progression
Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
Progression OR (95% CI) | p | Initial forward logistic regression model | Final logistic regression model | |||
Progression OR(95% CI) | p | Progression OR(95% CI) | p | |||
Age (above vs. below median) | 1.11(1.05–1.18) | <0.001 | 1.30(1.07–1.58) | 0.008 | 1.28(1.09–1.51) | 0.003 |
Gender (if female) | 1.47(0.62–3.51) | 3.59(0.62–20.89) | ||||
Hypertension (if present) | 9.58(2.64–34.79) | <0.001 | 0.75(0.03–19.49) | ns | ||
CKD stage | ||||||
4 | 1.00 | <0.001 | 1.00 | 0.032 | 1.00 | 0.014 |
3 (vs. stage 4) | 1.35(0.26–7.07) | ns | 0.02(0.01–1.32) | ns | 0.02(0.01–0.70) | 0.032 |
2 (vs. stage 4) | 0.08(0.01–0.49) | 0.007 | 0.01(0.01–0.12) | 0.007 | 0.01(0.01–0.07) | 0.004 |
1 (vs. stage 4) | 0.08(0.01–0.49) | 0.006 | 0.01(0.01–0.62) | 0.027 | 0.01(0.01–0.37) | 0.011 |
miR-3907 (above vs. below median) | 2.37(1.66–3.40) | <0.001 | 3.21(1.63–6.32) | 0.001 | 3.06(1.65–5.68) | <0.001 |