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Fig. 1 | BMC Nephrology

Fig. 1

From: Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

Fig. 1

Histological changes in renal tissues in response to cisplatin, rutin, and cisplatin plus rutin: a and b: photomicrographs of control rat kidney shows normal looking glomeruli (arrows) and the tubules (arrowheads) with no histological abnormality (hematoxylin-eosin stain, original magnification: ×200 and ×400 respectively). c: photomicrograph of rat kidney treated with rutin also show no significant pathological changes. d, e and f: photomicrographs of rat kidney treated with Cisplatin shows patchy lymphoplasmacytic mononuclear chronic inflammatory cell infiltrate in the interstitium (arrows) and patchy mild acute tubular epithelial cell injury (arrowheads) and scattered congested interstitial capillaries (hematoxylin-eosin stain, original magnifications: ×200, ×400 and ×400 respectively). g and h: more photomicrographs of rat kidney treated with Cisplatin showing reactive/reparative atypia of the injured tubular epithelial tubular cell in the form of enlarged nuclei and prominent nucleoli (arrow), many apoptotic tubular epithelial cells (arrowheads) along with focal cytoplasmic vacuolization the tubular epithelial cells (asterisk) (hematoxylin-eosin stain, original magnifications: ×400 and ×400 respectively). i: photomicrographs of rat kidney treated with Cisplatin and Rutin combination shows minimal focal tubular injury of few tubules (arrows) and minimal congestion of the interstitial capillaries (arrowhead) (hematoxylin-eosin stain, original magnification: ×400)

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