Skip to main content

Table 2 Renal effects of sepsis in pigs with and without AKI

From: Molecular differences in susceptibility of the kidney to sepsis-induced kidney injury

 

Baseline

12 h

18 h

22 h

Creatinine [umol/l]

 NON-AKI

99 [91–118]

95 [79–115]

98 [85–113]

101 [93–119]

 AKI

103 [97–110]

111 [94–131]

136 [117–164]*#

163 [137–217]*#

Renal Blood Flow [ml/min/kg]

 NON-AKI

6 [5–6]

4 [3–7]

5 [3–7]

4 [3–5]

 AKI

5 [4–8]

3 [2–4]

3 [1–5]*

1 [0.5–2]*#

Renal Vascular Resistance [mmHg/l/min]

 NON-AKI

422 [345–494]

385 [314–461]

320 [284–417]

417 [358–465]

 AKI

419 [321–637]

782 [537–1003]

1457 [567–2374]

2433 [1400–3886]*#

Renal cortical microcirculation (Laser Doppler Flowmetry) [% of baseline value]

 NON-AKI

100 [100–100]

108 [66–116]

100 [77–123]

84 [52–110]

 AKI

100 [100–100]

50 [28–61]*

50 [38–56]*

40 [27–57]*#

  1. Legend:
  2. *p < 0.05 vs. Baseline (RM ANOVA on Ranks; Dunn’s method of multiple comparisons)
  3. #p < 0.05 AKI vs. AKI-FREE(ANOVA on Ranks; Dunn’s method of multiple comparisons)