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Table 3 Hazard ratios for all-cause and cardiovascular mortality by indicators of CKD

From: Reduced Kidney Function, Albuminuria, and Risks for All-cause and Cardiovascular Mortality in China: A Population-based Cohort Study

Indicators of CKD Univariable model Multivariable adjusted model 1 Multivariable adjusted model 2 Multivariable adjusted model 3
All-cause mortality
eGFR ≥90 mL/min/1.73 m2 Reference Reference Reference Reference
  60–89 mL/min/1.73 m2 2.17(1.88–2.50) 0.98(0.84–1.16) 0.98(0.83–1.15) 0.96(0.82–1.13)
  <60 mL/min/1.73 m2 4.50(3.59–5.64) 1.13(0.88–1.47) 1.09(0.84–1.41) 1.03(0.79–1.34)
ACR <30 mg/g Reference Reference Reference Reference
  30-299 mg/g 1.74(1.44–2.11) 1.39(1.15–1.69) 1.26(1.04–1.53) 1.26(1.04–1.53)
  ≥300 mg/g 3.32(2.28–4.85) 2.29(1.57–3.35) 2.07(1.41–3.04) 2.07(1.40–3.04)
Cardiovascular mortality
eGFR ≥90 mL/min/1.73 m2 Reference Reference Reference Reference
  60–89 mL/min/1.73 m2 2.39(1.87–3.06) 0.95(0.72–1.26) 0.91(0.68–1.20) 0.89(0.67–1.18)
  <60 mL/min/1.73 m2 5.93(4.15–8.47) 1.20(0.79–1.82) 1.05(0.69–1.59) 0.99(0.65–1.50)
ACR <30 mg/g Reference Reference Reference Reference
  30-299 mg/g 1.69(1.22–2.34) 1.30(0.94–1.80) 1.08(0.78–1.50) 1.08(0.77–1.50)
  ≥300 mg/g 4.36(2.50–7.61) 2.84(1.63–4.97) 2.36(1.34–4.16) 2.32(1.31–4.12)
  1. Abbreviations: CKD chronic kidney disease, eGFR estimated glomerular filtration rate, ACR albumin creatinine ratio, LDL low density lipoprotein
  2. Effects of kidney damage markers on mortality were expressed as hazard ratios and 95% confidence intervals. Model 1 was adjusted for age, sex. Model 2 was adjusted for all variables in Model 1 plus education, current smoking, body mass index, hypertension, diabetes mellitus, cardiovascular disease history, use of nephrotoxic medication, rural or urban residents, high triglycerides, high LDL cholesterol. Model 3 was adjusted for all variables in Model 2 plus eGFR or ACR categories, as appropriate