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Table 3 Multivariate regression for the effect of white blood cell on renal function decline, rapid eGFR decline and incident CKD

From: White blood cell count predicts the odds of kidney function decline in a Chinese community-based population

Variables

Crude model

Adjusted model 1

Adjusted model 2

OR (95% CI)

OR (95% CI)

OR (95% CI)

Renal function decline

WBC continuous, 109/L

1.12 (1.04, 1.20)

1.14 (1.06, 1.22)

1.14 (1.06, 1.23)

WBC quartiles

   

 Quartile 1

1(Reference)

1(Reference)

1(Reference)

 Quartile 2

1.03 (0.71, 1.50)

1.06 (0.73, 1.54)

1.07 (0.72, 1.60)

 Quartile 3

1.29 (0.89, 1.87)

1.34 (0.92, 1.94)

1.45 (0.99, 2.15)

 Quartile 4

1.75 (1.23, 2.48)

1.89 (1.32, 2.69)

2.01 (1.38, 2.93)

 P-trend

<0.001

<0.001

<0.001

Rapid eGFR decline

WBC continuous, 109/L

1.10 (1.04, 1.15)

1.12 (1.06, 1.18)

1.11 (1.05, 1.17)

WBC quartiles

   

 Quartile 1

1(Reference)

1(Reference)

1(Reference)

 Quartile 2

1.09 (0.86, 1.37)

1.12 (0.89, 1.42)

1.11 (0.87, 1.41)

 Quartile 3

1.19 (0.94, 1.51)

1.24 (0.98, 1.57)

1.20 (0.94, 1.54)

 Quartile 4

1.43 (1.14, 1.80)

1.58 (1.25, 1.99)

1.49 (1.17, 1.91)

 P-trend

0.001

<0.001

<0.001

Incident CKD

WBC continuous, 109/L

1.41 (1.20, 1.64)

1.33 (1.09, 1.62)

1.36 (1.11, 1.68)

WBC quartiles

   

 Quartile 1

1(Reference)

1(Reference)

1(Reference)

 Quartile 2

1.33 (0.32, 5.58)

1.35 (0.30, 6.02)

1.72 (0.29, 10.25)

 Quartile 3

1.81 (0.45, 7.26)

1.73 (0.41, 7.37)

2.11 (0.38, 11.68)

 Quartile 4

4.70 (1.36, 16.17)

3.30 (0.90, 12.09)

4.79 (1.00, 23.00)

 P-trend

0.002

0.031

0.018

  1. Model 1: adjusted for age, sex, and eGFR at baseline
  2. Model 2: adjusted for variables in model 1 and body mass index, current smoking, current drinking, hypertension, diabetes mellitus, dyslipidemia, history of cardiovascular disease, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs
  3. Abbreviations: WBC white blood cell, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, OR odd ratio, CI confidence interval