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Table 3 Multivariate regression for the effect of white blood cell on renal function decline, rapid eGFR decline and incident CKD

From: White blood cell count predicts the odds of kidney function decline in a Chinese community-based population

Variables Crude model Adjusted model 1 Adjusted model 2
OR (95% CI) OR (95% CI) OR (95% CI)
Renal function decline
WBC continuous, 109/L 1.12 (1.04, 1.20) 1.14 (1.06, 1.22) 1.14 (1.06, 1.23)
WBC quartiles    
 Quartile 1 1(Reference) 1(Reference) 1(Reference)
 Quartile 2 1.03 (0.71, 1.50) 1.06 (0.73, 1.54) 1.07 (0.72, 1.60)
 Quartile 3 1.29 (0.89, 1.87) 1.34 (0.92, 1.94) 1.45 (0.99, 2.15)
 Quartile 4 1.75 (1.23, 2.48) 1.89 (1.32, 2.69) 2.01 (1.38, 2.93)
 P-trend <0.001 <0.001 <0.001
Rapid eGFR decline
WBC continuous, 109/L 1.10 (1.04, 1.15) 1.12 (1.06, 1.18) 1.11 (1.05, 1.17)
WBC quartiles    
 Quartile 1 1(Reference) 1(Reference) 1(Reference)
 Quartile 2 1.09 (0.86, 1.37) 1.12 (0.89, 1.42) 1.11 (0.87, 1.41)
 Quartile 3 1.19 (0.94, 1.51) 1.24 (0.98, 1.57) 1.20 (0.94, 1.54)
 Quartile 4 1.43 (1.14, 1.80) 1.58 (1.25, 1.99) 1.49 (1.17, 1.91)
 P-trend 0.001 <0.001 <0.001
Incident CKD
WBC continuous, 109/L 1.41 (1.20, 1.64) 1.33 (1.09, 1.62) 1.36 (1.11, 1.68)
WBC quartiles    
 Quartile 1 1(Reference) 1(Reference) 1(Reference)
 Quartile 2 1.33 (0.32, 5.58) 1.35 (0.30, 6.02) 1.72 (0.29, 10.25)
 Quartile 3 1.81 (0.45, 7.26) 1.73 (0.41, 7.37) 2.11 (0.38, 11.68)
 Quartile 4 4.70 (1.36, 16.17) 3.30 (0.90, 12.09) 4.79 (1.00, 23.00)
 P-trend 0.002 0.031 0.018
  1. Model 1: adjusted for age, sex, and eGFR at baseline
  2. Model 2: adjusted for variables in model 1 and body mass index, current smoking, current drinking, hypertension, diabetes mellitus, dyslipidemia, history of cardiovascular disease, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs
  3. Abbreviations: WBC white blood cell, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, OR odd ratio, CI confidence interval