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Table 5 Bivariate regression analysis: variables associated with the dp-ucMGP drop divided by the median (90%)

From: High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial

  Dp-ucMGP drop ≤90% N = 23 Dp-ucMGP drop >90% N = 27 P-value OR (95% CI)
Age (years), Median (IQR) 72.0 (55.0; 80.0) 69.0 (63.0; 79.0) 0.63 1.01 (0.97–1.05)
Gender, male n (%) 14 (60) 16 (59.3) 1.00 1.07 (0.34–3.33)
Dialysis vintage (months), Median (IQR) 41.0 (28.0; 112.0) 48.0 (22.0; 110.0) 0.68 1.02 (0.92–1.14)
Diabetes, n (%) 13 (56.5) 5 (18.5) 0.01 0.17 (0.05–0.62)
Hypertension, n (%) 16 (69.6) 22 (81.5) 0.32 1.92 (0.52–7.18)
Smoking, n (%) 3 (13.0) 5 (18.5) 0.71 1.51 (0.32–7.17)
Calcification score, Median (IQR) 3.0 (1.0; 12.0) 9.0 (4.0; 14.0) 0.10 1.06 (0.97–1.15)
NCBB, n (%) 10 (43.5) 10 (37.0) 0.64 0.76 (0.25–2.38)
Residual diuresis, n (%) 3 (13.0) 3 (11.1) 1.00 0.83 (0.15–4.59)
Calcium dose, Median (IQR) 2.0 (1.0; 3.0) 1.0 (1.0; 2.0) 0.12 0.63 (0.36–1.11)
Alfacalcidol dose (μg), Median (IQR) 0.75 (0.00; 1.50) 0.75 (0.25; 1.50) 0.20 1.17 (0.82–1.69)
Serum phosphate (mg/dl), Median (IQR) 3.90 (3.50; 5.00) 3.90 (3.00; 4.50) 0.25 0.64 (0.39–1.06)
Serum calcium (mg/dl), Median (IQR) 9.00 (8.70; 9.30) 9.20 (8.90; 9.30) 0.08 4.97 (0.82–30.06)
PTH (pg/ml), Median (IQR) 153.00 (88.50; 216.00) 216.0 (144.0; 314.0) 0.10 1.03 (0.98–1.07)
LDL cholesterol (mg/dl), Median (IQR) 93.50 (77.75; 114.25) 92.00 (76.00; 113.25) 0.61 0.99 (0.97–1.02
BMI (Kg/m2), Median (IQR) 26.45 (23.03; 31.39) 25.26 (22.65; 26.65) 0.13 0.89 (0.78–1.01)
URR, Median (IQR) 75.0 (71.0; 79.0) 74.0 (71.0; 79.0) 0.70 0.98 (0.88–1.10)
Albumin, Median (IQR) 37.0 (35.0; 40.0) 39.0 (37.0; 41.0) 0.15 1.09 (0.94–1.26)
CAD, n (%) 7 (30.4) 7 (25.9) 0.72 0.80 (0.23–2.76)
Cinacalcet, n (%) 1 (4.3) 1 (3.7) 1.00 0.85 (0.05–14.33)
Previous acenocoumadin, n (%) 3 (13.0) 3 (11.1) 1.00 0.83 (0.15–4.59)
PTHX, n (%) 0 (0.0) 2 (7.4) 0.49 NA
Recent fracture, n (%) 1 (4.3) 2 (7.4) 1.00 1.76 (0.15–20.76)
  1. Abbreviations: NCBB non-calcium-based phosphate binders, PTH intact parathyroid hormone, BMI body mass index, URR urea reduction ratio, CAD documented coronary artery disease, PTHX, previous parathyroidectomy