Fig. 3

Representative images of kidney biopsy performed on post-operative day 12. (a) A low power image of three of the five core biopsies, with two of the visualized cores demonstrating extensive cortical necrosis. Original magnification 12.5X. (b – c) Higher power images of areas of cortical necrosis, with evidence of complete destruction of glomerular and tubular structures, and associated inflammatory infiltrates. Original magnification 100X. Areas of preserved cortex demonstrated (d) capillaritis and interstitial inflammation, (e) tubulitis, and (f) peritubular capillary C4d staining. Original magnification 400X