Fig. 1

UUO-induced JG hyperplasia and AT1R and α-SMA expression. a Lymphocyte infiltration subsequently increased gradually, and renal fibrosis developed. TSA treatment suppressed JG hyperplasia in the UUO mice (400X). b CD4⁺IL-17⁺, CD4⁺FOXP3⁺ and FOXP3⁺IL-17⁺ T cells appeared in obstructed kidneys after UUO. (FOXP3⁺IL-17⁺ double stain: IL-17, blue; FOXP3, red. CD4⁺IL-17⁺ or CD4⁺FOXP3⁺ stain: CD4, red; IL-17 and FOXP3, brown, 400X). c The numbers of CD4⁺IL-17⁺, CD4⁺FOXP3⁺ and FOXP3⁺IL-17⁺ T cells (cells/HPF) in obstructed kidneys after UUO. *: p < 0.05