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Fig. 4 | BMC Nephrology

Fig. 4

From: The attenuation of renal fibrosis by histone deacetylase inhibitors is associated with the plasticity of FOXP3+IL-17+ T cells

Fig. 4

CD4+FOXP3+IL-17+ T cells in a single-cell suspension from renal tissues from UUO mice treated with or without TSA. The cells were subjected to membrane and intracellular staining and were analyzed by fluorescence-activated cell sorting (FACS). a-b Fresh single-cell suspensions prepared from 14- and 21-days UUO ligated kidneys (CD4 gated). c TSA increased the appearance of apoptotic IL-17+Annexin+ cells (CD4 gated). d Flow cytometry (CD4 gated) detected splenic IL-17+FOXP3+TGF-β1+ T cells, the percentage of which was increased after UUO for 7 or 14 days. After TSA treatment, this percentage decreased

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