Fig. 1
From: Long-term renal survival of γ3-heavy chain deposition disease: a case report
a and b On light microscopy, 13 glomerules are present, and none are globally sclerotic. All glomerules reveal similar findings. The interstitial architecture shows mild interstitial fibrosis and tubular atrophy. There is focal infiltration of inflammatory cells. Cast formation is not observed. Masson’s trichrome staining, original magnification (a) 40 (b) 200×. (c) and (d) Representative glomerules are lobulated and have nodular mesangial sclerosis with mesangial cell proliferation. Periodic acid-Schiff staining, original magnification (c) 100× (d) 400×. (e) and (f) Representative glomerules show nodular glomerulosclerosis markedly. Capillary walls are thickened, and duplication of glomerular basement membranes is observed. Endocapillary proliferation with mesangiolysis is detected in the focal segmental lesion. Adhesion to Bowman’s capsule is also seen. Periodic acid-methenamine silver staining, original magnification 400×