Table 1 Literature of TEN causes (case series of five or more pediatric patients 2009–2015)

Quirke et al. (2015) [7]

N = 41 (BSA > 30%: n = 23, BSA ≤ 30%; n = 16, unknown; n = 2:)

11.2 ± 4.6

1.4 ± 0.7

39.7 ± 26.0

ND

Drugs (90%: anticonvulsants, antibiotics, NSAIDS, others), mycoplasma pneumoniae (5%), unknown (5%)

ND

Corticosteroids (54%), IVIG (17%), supplemental nutritional support (90%), required mechanical ventilation (51%)

Mortality

(0%)

Hamilton et al. (2013) [8]

N = 10 (BSA 20–30%: n = 4, BSA > 30%: n = 4, unknown: n = 2)

6.6 ± 3.9

1.7 ± 0.5

42.2 ± 20.6

ND

Drugs (70%: anticonvulsants, antibiotics, others), mycoplasma infection (20%), unknown (10%)

ND

IVIG (80%), corticosteroids (20%), antibiotics (60%)

Mortality

(0%)

Finkelstein et al. (2011) [9]

N = 55 (TEN: n = 5, SJS: n = 47, SJS/TEN: n = 3)

9.6 ± 4.8

ND

ND

ND

Drugs (anticonvulsants: 29%, antibiotics: 20%, chemotherapy drugs: 2%), infections (mycoplasma pneumonia: 22%, herpes simplex virus: 9%), undetermined (18%)

ND^a

Supportive care (100%), antibiotics (67%), antiviral (38%), corticosteroids (40%), IVIG (38%), corticosteroids plus IVIG (14%)

Mortality

(2%)

Ferradiz et al. (2011) [10]

N = 14 (TEN: n = 6, SJS: n = 8)

10.4 (range: 1–17)

ND

60 (range: 10–96)

16.5 (1–30)

Suspicious drugs (anticonvulsants: 50%, antiviotics: 36%, NSAIDS: 21%)

ND

Supportive care (100%), corticosteroids: 1-2 mg/kg/day, 9 days (86%), IVIG: 1-2 g/kg/day, 3 days (29%), silversulfadiazine dressings (71%)

Mortality (7%)

Levi et al. (2009) [1]

N = 80 (TEN: n = 27, SJS: n = 21, SJS/TEN: n = 32)

6.2 (IQR: 3.7–9.9)

ND

20 (range: 10–40)

6 (range; 1–17)^b

Drugs (anticonvulsants: 30%, antiviotics: 40%, others), mycoplasma pneumoniae (9%)

ND

ND

Mortality (7.5%)