All | Decreased GFR (n = 271) | Preserved GFR (n = 2915) | P value | |
---|---|---|---|---|
Age, years | 51.3 ± 7.4 | 55.1 ± 8.2 | 50.9 ± 7.2 | <0.001 |
Female sex, % | 29.5 (940) | 15.5 (42) | 30.8 (898) | <0.001 |
Diabetes, % | 7.8 (244) | 17.7 (47) | 6.9 (197) | <0.001 |
Systolic blood pressure, mm Hg | 122.3 ± 17.2 | 132.4 ± 20.8 | 121.4 ± 16.5 | <0.001 |
Waist circumference, cm. | 86.3 ± 9.6 | 89.9 ± 9.1 | 85.9 ± 9.6 | <0.001 |
Hypertension, % | 15.9 (495) | 31.6 (85) | 14.4 (410) | <0.001 |
High density lipoprotein cholesterol, mg/dL | 54.6 ± 14.7 | 52.2 ± 13.3 | 54.8 ± 14.8 | 0.005 |
Triglycerides, mg/dL | 146.2 ± 99.8 | 162.2 ± 99.9 | 144.7 ± 99.7 | 0.006 |
Total cholesterol, mg/dL | 237.0 ± 41.8 | 236.1 ± 45.2 | 237.1 ± 41.5 | 0.704 |
Blood sugar, mg/dL | 99.5 ± 25.5 | 109.5 ± 37.6 | 98.6 ± 23.9 | <0.001 |
Body mass index, kg/m2 | 24.3 ± 3.5 | 25.2 ± 3.4 | 24.3 ± 3.5 | <0.001 |
BMI ≥ 30 kg/m2, % | 7.1 (222) | 9.0 (24) | 6.9 (198) | 0.197 |
BMI ≥ 25 kg/m2, % | 44.5 (1401) | 57.7 (154) | 43.3 (1247) | <0.001 |
Current smoking, % | 16.2 (509) | 17.5 (47) | 16.1 (462) | <0.001 |
Cardiovascular disease, %a | 1.3 (42) | 2.6 (7) | 1.2 (35) | 0.056 |
Serum creatinine, mg/dl | 1.00 ± 0.18 | 1.10 ± 0.18 | 0.99 ± 0.18 | <0.001 |
Estimate glomerular filtration rate, mL/min/1.73m2 | 81.8 ± 12.6 | 73.1 ± 12.3 | 82.6 ± 12.4 | <0.001 |
Categorical eGFR, mL/min/1.73m2 | <0.001 | |||
60–74 mL/min/1.73m2, % | 27.3 (870) | 68.3 (185) | 30.8 (898) | |
75–89 mL/min/1.73m2, % | 38.7 (1233) | 21.8 (59) | 40.3 (1174) | |
90–119 mL/min/1.73m2, % | 34.0 (1083) | 10.0 (27) | 28.9 (843) | |
Dipstick proteinuria, % | 15.9 (187) | 25.2 (33) | 14.8 (154) | 0.002 |
Serum Uric acid, mg/dL | 5.6 ± 1.4 | 6.4 ± 1.5 | 5.6 ± 1.4 | <0.001 |
Hemoglobin, mg/dL | 14.4 ± 1.5 | 14.6 ± 1.4 | 14.4 ± 1.5 | 0.046 |