|
Variable
|
Total n = 279,956
|
RLS n = 372
|
NSD n = 279,584
|
P
|
|---|
|
Incidence age, years
|
62.05 ± 15.39
|
64.22 ± 15.64
|
62.04 ± 15.39
|
0.007
|
|
Gender
| | | |
0.2
|
|
Female
|
43.72 (122,400)
|
47.3 (176)
|
43.7 (122,224)
| |
|
Male
|
56.28 (157,556)
|
52.7 (196)
|
56.3 (157,360)
| |
|
Race
| | | |
<.0001
|
|
White
|
64.38 (180,239)
|
86.29 (321)
|
64.35 (179,918)
| |
|
Black
|
29.93 (83,782)
|
11.56 (43)
|
29.95 (83,739)
| |
|
Asian
|
3.32 (9282)
|
1.34 (5)
|
3.32 (9277)
| |
|
Native American
|
1.08 (3026)
|
0.27 (1)
|
1.08 (3025)
| |
|
Other/Unknown
|
1.3 (3627)
|
0.54 (2)
|
1.3 (3625)
| |
|
Ethnicity
| | | |
0.002
|
|
Non-Hispanic/Latino
|
85.68 (239,880)
|
91.4 (340)
|
85.68 (239,540)
| |
|
Hispanic/Latino
|
14.32 (40,076)
|
8.6 (32)
|
14.32 (40,044)
| |
|
Vascular access type
| | | |
0.0002
|
|
AV Fistula
|
14.61 (40,902)
|
23.12 (86)
|
14.6 (40,816)
| |
|
Graft
|
3.95 (11,058)
|
4.3 (16)
|
3.95 (11,042)
| |
|
Catheter
|
80.28 (224,739)
|
71.77 (267)
|
80.29 (224,472)
| |
|
Other/Unknown
|
1.16 (3257)
|
0.81 (3)
|
1.16 (3254)
| |
|
Body mass index (kg/m2)f
|
28.74 ± 7.71
|
28.98 ± 7.57
|
28.74 ± 7.71
|
0.5
|
|
Serum creatinine (mg/dl)f
|
6.58 ± 3.46
|
6.64 ± 3.74
|
6.58 ± 3.46
|
0.8
|
|
Serum albumin (g/dl)f
|
3.11 ± 0.71
|
3.32 ± 0.64
|
3.11 ± 0.71
|
<.0001
|
|
Anemiaa
|
8.37 (23,432)
|
11.83 (44)
|
8.37 (23,388)
|
0.02
|
|
Cardiovascular
|
|
Coronary artery diseaseb
|
21.09 (59,054)
|
17.2 (64)
|
21.1 (58,990)
|
0.07
|
|
Congestive heart failure
|
32.18 (90,088)
|
26.34 (98)
|
32.19 (89,990)
|
0.02
|
|
Cerebrovascular disease
|
9.4 (26,329)
|
8.06 (30)
|
9.41 (26,299)
|
0.4
|
|
Peripheral vascular disease
|
14.04 (39,301)
|
10.22 (38)
|
14.04 (39,263)
|
0.03
|
|
Hypertension
|
84.92 (237,737)
|
83.6 (311)
|
84.92 (237,426)
|
0.5
|
|
Other
|
|
Diabetes
|
52.78 (147,771)
|
38.98 (145)
|
52.8 (147,626)
|
<.0001
|
|
Cancer
|
6.81 (19,065)
|
5.91 (22)
|
6.81 (19,043)
|
0.5
|
|
Sleep disorders
|
|
Any sleep disorder
|
0.13 (372)
|
100.0 (372)
|
0 (0)
|
<.0001
|
|
Restless legs syndrome
|
0.13 (372)
|
100.0 (372)
|
0 (0)
|
<.0001
|
|
Obstructive sleep apnea
|
0.01 (17)
|
4.57 (17)
|
0 (0)
|
<.0001
|
|
Psychological disorders
|
|
Major depressive disorder
|
0.37 (1030)
|
1.61 (6)
|
0.37 (1024)
|
<.0001
|
|
Dysthymic disorder
|
0.26 (727)
|
2.15 (8)
|
0.26 (719)
|
<.0001
|
|
Anxiety
|
0.6 (1691)
|
4.03 (15)
|
0.6 (1676)
|
<.0001
|
|
Adjustment disorder
|
0.03 (81)
|
0.27 (1)
|
0.03 (80)
|
0.1
|
|
Depressionc
|
0.65 (1829)
|
4.03 (15)
|
0.65 (1814)
|
<.0001
|
|
Minor depressive disorderd
|
0.29 (808)
|
2.42 (9)
|
0.29 (799)
|
<.0001
|
|
Psychological disordere
|
1.24 (3459)
|
8.06 (30)
|
1.23 (3429)
|
<.0001
|
|
Tobacco dependence
|
6.39 (17,887)
|
8.87 (33)
|
6.39 (17,854)
|
0.05
|
|
Alcohol dependence
|
1.57 (4384)
|
0.81 (3)
|
1.57 (4381)
|
0.2
|
|
Drug dependence
|
1.55 (4339)
|
1.08 (4)
|
1.55 (4335)
|
0.5
|
- Age and clinical measures are mean ± SD. Categorical data are percentages (counts). No sleep disorder diagnosed (NSD)
-
aDetermined by ICD-9-CM codes 280.0–280.9, 285.0, 285.2, 285.8, 285.9
-
bAtherosclerosis, myocardial infarction (MI), ischemic heart disease (IHD)
-
cmajor depressive disorder, dysthymic disorder, adjustment disorder
-
dDysthymic disorder, adjustment disorder
-
eDepression, anxiety
-
fMissing data points
