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Table 2 Definition of Early and Late RRT in Studies Included in the Meta-analysis

From: A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Author Year Early RRT Criteria Late RRT Criteria
Bouman 2002 RRT within 12 h if urine output <30 ml/h, Cr clearance <20 ml/min, and mechanical ventilation Urea > 40 mmol/L or K > 6.5 mmol/L or severe pulmonary edema
Durmaz 2003 Preoperative prophylactic RRT in all patients and postoperative sCr increased >10% Postoperative sCr increased >50% or urine output <400 ml/24 h
Sugahara 2004 Urine output <30 ml/h for 3 h or urine output <750 ml/day Urine output <20 ml/h for 2 h or urine output <500 ml/day
Payen 2009 RRT for 96-h period within 24 h of diagnosis of severe sepsis Classic indications for RRT
Jamale 2013 Serum urea nitrogen >70 mg/dL and/or creatinine >7 mg/dL Classic indications for RRT or Uremic nausea and anorexia
Combes 2015 RRT within 24 h of diagnosis of post-cardiac surgery shock Creatinine >4 mg/dL or preoperative creatinine × 3 or urine output <0.3 ml/kg/h /24 h or urea >36 mmol/L or life-threatening hyperkalemia
Wald 2015 sCr increased >200%, urine output <6 ml/kg within 12 h, or NGAL ≥ 400 ng/ml K > 6.0 mmol/L or serum bicarbonate <10 mmol/L or pulmonary edema
Gaudry 2016 RRT within 6 h of diagnosis of KDIGO stage 3 K > 6.0 mmol/L or PH < 7.15 or pulmonary edema or blood urea nitrogen >112 mg/dL or oliguria >72 h
Zarbock 2016 RRT within 8 h of diagnosis of KDIGO stage 2 RRT within 12 h of KDIGO stage 3 or no RRT
  1. Abbreviations: RRT renal replacement therapy, Cr creatinine, sCr serum creatinine, K potassium, KDIGO kidney disease: improving global outcomes, NGAL neutrophil gelatinase-associated lipocalin