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Table 2 Definition of Early and Late RRT in Studies Included in the Meta-analysis

From: A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Author

Year

Early RRT Criteria

Late RRT Criteria

Bouman

2002

RRT within 12 h if urine output <30 ml/h, Cr clearance <20 ml/min, and mechanical ventilation

Urea > 40 mmol/L or K > 6.5 mmol/L or severe pulmonary edema

Durmaz

2003

Preoperative prophylactic RRT in all patients and postoperative sCr increased >10%

Postoperative sCr increased >50% or urine output <400 ml/24 h

Sugahara

2004

Urine output <30 ml/h for 3 h or urine output <750 ml/day

Urine output <20 ml/h for 2 h or urine output <500 ml/day

Payen

2009

RRT for 96-h period within 24 h of diagnosis of severe sepsis

Classic indications for RRT

Jamale

2013

Serum urea nitrogen >70 mg/dL and/or creatinine >7 mg/dL

Classic indications for RRT or Uremic nausea and anorexia

Combes

2015

RRT within 24 h of diagnosis of post-cardiac surgery shock

Creatinine >4 mg/dL or preoperative creatinine × 3 or urine output <0.3 ml/kg/h /24 h or urea >36 mmol/L or life-threatening hyperkalemia

Wald

2015

sCr increased >200%, urine output <6 ml/kg within 12 h, or NGAL ≥ 400 ng/ml

K > 6.0 mmol/L or serum bicarbonate <10 mmol/L or pulmonary edema

Gaudry

2016

RRT within 6 h of diagnosis of KDIGO stage 3

K > 6.0 mmol/L or PH < 7.15 or pulmonary edema or blood urea nitrogen >112 mg/dL or oliguria >72 h

Zarbock

2016

RRT within 8 h of diagnosis of KDIGO stage 2

RRT within 12 h of KDIGO stage 3 or no RRT

  1. Abbreviations: RRT renal replacement therapy, Cr creatinine, sCr serum creatinine, K potassium, KDIGO kidney disease: improving global outcomes, NGAL neutrophil gelatinase-associated lipocalin