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Table 4 Subgroup Meta-analyses and Meta regression Analyses

From: A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Subgroup No. of Studies No. of Patients Random-Effects Model RR (95% CI) Test for Effect P I2(%) Test for Heterogeneity P Meta regression P
All Studies 9 1636 0.98 (0.78, 1.23) 0.84 60 0.01  
Study Design        0.216
 Single-center 4 511 0.58 (0.25, 1.36) 0.21 78 0.003  
 Multicenter 5 1125 1.03 (0.91, 1.17) 0.61 0 0.75  
Sample Size        0.362
  < 100 3 148 0.37 (0.07, 1.90) 0.23 82 0.004  
  ≥ 100 6 1488 1.00 (0.83, 1.21) 0.98 44 0.11  
Patient Population        
 Multisystem 6 1340 1.00 (0.82, 1.22) 0.99 42 0.120  
 Post cardiac surgery 3 296 0.37 (0.07, 1.81) 0.22 83 0.003  
RRT Modality        0.838
 CVVH 5 665 0.91 (0.63, 1.32) 0.62 71 0.007  
 IHD 2 252 0.63 (0.06, 6.19) 0.69 79 0.03  
 CVVH/IHD 2 719 0.98 (0.84, 1.14) 0.75 0 0.84  
Days of Follow up        0.681
  < 60 4 254 0.65 (0.30, 1.43) 0.29 74 0.009  
  ≥ 60 5 1382 0.99 (0.80, 1.23) 0.95 53 0.07  
Creatinine Difference        0.632
 Significant 4 583 0.92 (0.55, 1.53) 0.74 67 0.03  
 Nonsignificant 5 1053 1.02 (0.78, 1.33) 0.87 57 0.05  
UO Difference        0.079
 Significant 2 259 0.40 (0.10, 1.63) 0.20 78 0.03  
 Nonsignificant 5 1227 1.05 (0.92, 1.19) 0.48 0 0.42  
KDIGO        0.334
 stage 1–2 5 627 0.74 (0.47, 1.17) 0.20 72 0.01  
 stage 3 3 933 1.08 (0.84, 1.40) 0.54 31 0.23  
  1. Abbreviations: RRT renal replacement therapy, EHV early high volume, ELV early low volume, LLV late low volume, CVVH continuous venovenous hemoflitration, IHD intermittent hemodialysis, UO urinary output, KDIGO kidney disease: improving global outcomes