|
Predictors
|
Male
|
Female
|
|---|
|
HRa
|
95%CI
|
P-value
|
HRa
|
95%CI
|
P-value
|
|---|
|
Socio-demographics
|
|
Age, years
|
1.06
|
(1.05,1.08)
|
<0.001*
|
1.03
|
(1.02,1.05)
|
<0.001*
|
|
Smoker (Non-smoker)
|
1.29
|
(1.11,1.50)
|
0.001*
| | | |
|
Disease characteristics
|
|
Duration of T2DM, years
| | | |
1.01
|
(1.00,1.02)
|
0.046*
|
|
STDR (No)
|
1.47
|
(1.18,1.84)
|
0.001*
| | | |
|
Treatment modalities
|
|
Anti-hypertensive drugs used (No)
|
1.54
|
(1.21,1.97)
|
0.001*
|
1.66
|
(1.21,2.26)
|
0.002*
|
|
Oral drug (No)
|
1.37
|
(1.07,1.75)
|
0.011*
|
1.98
|
(1.43,2.75)
|
<0.001*
|
|
Insulin drug (No)
|
9.79
|
(1.66,57.62)
|
0.012*
|
1.73
|
(1.30,2.29)
|
<0.001*
|
|
Clinical parameters
|
|
BMI, kg/m2
| | | |
0.85
|
(0.77,0.95)
|
0.002*
|
|
BMI2, kg/m2
| | | |
1.003
|
(1.001,1.005)
|
0.001*
|
|
HbA1c, %
|
0.79
|
(0.64,0.98)
|
0.036*
|
0.70
|
(0.49,0.99)
|
0.046*
|
|
HbA1c2, %
|
1.02
|
(1.01,1.03)
|
0.002*
|
1.03
|
(1.01,1.05)
|
0.013*
|
|
SBP, mmHg
|
1.01
|
(1.01,1.02)
|
<0.001*
|
1.01
|
(1.00,1.01)
|
0.025*
|
|
DBP, mmHg
|
0.93
|
(0.88,0.98)
|
0.009*
|
0.92
|
(0.86,0.98)
|
0.007*
|
|
DBP2, mmHg
|
1.0004
|
(1.0000,1.0008)
|
0.039*
|
1.001
|
(1.000,1.001)
|
0.017*
|
|
ln(Urine ACR + 1), mg/mmol
|
3.15
|
(2.11,4.69)
|
<0.001*
|
1.45
|
(1.37,1.53)
|
<0.001*
|
|
eGFR (>90 ml/min/1.73m2)
|
|
60-89 ml/min/1.73m2
|
2.45
|
(2.08,2.88)
|
<0.001*
|
2.00
|
(0.38,10.51)
|
0.412
|
|
< 60 ml/min/1.73m2
|
8.76
|
(7.08,10.84)
|
<0.001*
|
112.06
|
(23.97,523.76)
|
<0.001*
|
|
Age interaction term
|
|
Age*eGFR(>90 ml/min/1.73m2)
|
|
60-89 ml/min/1.73m2
| | | |
1.003
|
(0.979,1.028)
|
0.816
|
|
< 60 ml/min/1.73m2
| | | |
0.97
|
(0.95,0.99)
|
0.006*
|
|
Age*insulin
|
0.97
|
(0.95,1.00)
|
0.028*
| | | |
|
Age* ln(Urine ACR + 1)
|
0.99
|
(0.98,0.99)
|
<0.001*
| | | |
-
T2DM Type 2 Diabetes Mellitus, STDR Sight Threatening Diabetic Retinopathy, BMI Body Mass Index, HbA1c Hemogloblin A1c, SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, TC Total Cholesterol, HDL-C High-density Lipoprotein-Cholesterol, ACR Albumin/Creatinine Ratio, eGFR estimated Glomerular Filtration Rate, T2DM Type 2 Diabetes Mellitus, HR Hazard Ratio
- * Significant difference (P < 0.05)
-
a HR > 1 indicates greater risk of event occurrence
