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Table 2 Cox regression models for predictors of developing end stage renal disease in derivation cohort

From: Prediction of new onset of end stage renal disease in Chinese patients with type 2 diabetes mellitus – a population-based retrospective cohort study

Predictors Male Female
HRa 95%CI P-value HRa 95%CI P-value
Socio-demographics
 Age, years 1.06 (1.05,1.08) <0.001* 1.03 (1.02,1.05) <0.001*
 Smoker (Non-smoker) 1.29 (1.11,1.50) 0.001*    
Disease characteristics
 Duration of T2DM, years     1.01 (1.00,1.02) 0.046*
 STDR (No) 1.47 (1.18,1.84) 0.001*    
Treatment modalities
 Anti-hypertensive drugs used (No) 1.54 (1.21,1.97) 0.001* 1.66 (1.21,2.26) 0.002*
 Oral drug (No) 1.37 (1.07,1.75) 0.011* 1.98 (1.43,2.75) <0.001*
 Insulin drug (No) 9.79 (1.66,57.62) 0.012* 1.73 (1.30,2.29) <0.001*
Clinical parameters
 BMI, kg/m2     0.85 (0.77,0.95) 0.002*
 BMI2, kg/m2     1.003 (1.001,1.005) 0.001*
 HbA1c, % 0.79 (0.64,0.98) 0.036* 0.70 (0.49,0.99) 0.046*
 HbA1c2, % 1.02 (1.01,1.03) 0.002* 1.03 (1.01,1.05) 0.013*
 SBP, mmHg 1.01 (1.01,1.02) <0.001* 1.01 (1.00,1.01) 0.025*
 DBP, mmHg 0.93 (0.88,0.98) 0.009* 0.92 (0.86,0.98) 0.007*
 DBP2, mmHg 1.0004 (1.0000,1.0008) 0.039* 1.001 (1.000,1.001) 0.017*
 ln(Urine ACR + 1), mg/mmol 3.15 (2.11,4.69) <0.001* 1.45 (1.37,1.53) <0.001*
 eGFR (>90 ml/min/1.73m2)
  60-89 ml/min/1.73m2 2.45 (2.08,2.88) <0.001* 2.00 (0.38,10.51) 0.412
  < 60 ml/min/1.73m2 8.76 (7.08,10.84) <0.001* 112.06 (23.97,523.76) <0.001*
 Age interaction term
 Age*eGFR(>90 ml/min/1.73m2)
  60-89 ml/min/1.73m2     1.003 (0.979,1.028) 0.816
  < 60 ml/min/1.73m2     0.97 (0.95,0.99) 0.006*
 Age*insulin 0.97 (0.95,1.00) 0.028*    
 Age* ln(Urine ACR + 1) 0.99 (0.98,0.99) <0.001*    
  1. T2DM Type 2 Diabetes Mellitus, STDR Sight Threatening Diabetic Retinopathy, BMI Body Mass Index, HbA1c Hemogloblin A1c, SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, TC Total Cholesterol, HDL-C High-density Lipoprotein-Cholesterol, ACR Albumin/Creatinine Ratio, eGFR estimated Glomerular Filtration Rate, T2DM Type 2 Diabetes Mellitus, HR Hazard Ratio
  2. * Significant difference (P < 0.05)
  3. a HR > 1 indicates greater risk of event occurrence