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Table 1 Clinical characteristics

From: Urine neutrophil gelatinase-associated lipocalin to predict renal response after induction therapy in active lupus nephritis

Variables

N (%) or mean ± SD

Median with IQR

Female (N, %)

66 (97.1%)

 

Age (years)

31.7 ± 10.0

32 (23, 38)

Body weight (kg)

54.7 ± 14.9

50.9 (45.9, 62)

Body mass index

20.1 ± 3.9

 

Duration of SLE (years)

6.3 ± 6.3

4 (2, 8.5)

Systolic blood pressure (mmHg)

126.7 ± 24.3

128 (119, 138.5)

Diastolic blood pressure (mmHg)

79.4 ± 19.2

78.5 (70, 92)

Systemic organ involvements (N, %)

 Arthritis

14 (20.6%)

 

 Cutaneous lupus

14 (20.6%)

 

 Hematologic involvement

8 (11.8%)

 

 Serositis

4 (5.9%)

 

 Neurological involvement

1 (1.5%)

 

Baseline SLEDAI score

10.8 ± 3.3

10 (8, 12)

Baseline Renal SLEDAI score

7.0 ± 2.9

8 (4, 8)

ISN/RPS class (N, %)

 Class III

5 (7.4%)

 

 Class IV

49 (72.1%)

 

 Class III + V

4 (5.9%)

 

 Class IV + V

10 (14.7%)

 

Renal activity index

8.5 ± 2.9

8 (6, 11.5)

Renal chronicity index

1.9 ± 1.7

2 (0, 3)

Immunosuppressive agents (N, %)

 Induction with high cyclophosphamide

37 (62.7%)

 

 Induction with mycophenolate

22 (37.3%)

 

 Mean dose of mycophenolate (mg/day)

29.6 ± 17.1

30 (20, 35)

 Prednisolone

67 (98.5%)

 

 Hydroxychloroquine

32 (47.1%)

 

Anti-hypertensive and lipid lowering agents (N, %)

 RAAS blockers

51 (75%)

 

 Calcium channel blockers

10 (14.7%)

 

 Diuretics

28 (41.2%)

 

 Statins

43 (63.2%)

 

Laboratory data

 Positive ANA (%)

67 (98.5%)

 

 Positive anti-dsDNA (%)

57 (83.8%)

 

 Low complement component 3 (C3) (%)

31 (60.8%)

 

 Serum complement component C3 levels (g/L)

1.2 ± 1.8

0.7 (0.4, 1.1)

 Hematocrit (%)

26.5 ± 11.2

30 (13.7, 34.6)

 Serum albumin (g/dL)

2.7 ± 0.9

3 (2, 3.2)

 Serum creatinine (mg/dL)

0.9 ± 0.5

0.8 (0.7, 1.1)

 Estimated GFR (mL/min/1.73 m2)

89.6 ± 33.7

89.4 (63.7, 116.8)

 UPCR (g/g creatinine)

5.9 ± 4.8

4.8 (2.5, 6.9)

  1. Abbreviations ANA antinuclear antibody, Anti-dsDNA anti-double-stranded DNA antibody, ISN/RPS International Society of Nephrology/Renal Pathology Society, GFR glomerular filtration rate, RAAS renin angiotensin aldosterone system, SLEDAI systemic lupus erythematosus disease activity index, UPCR urine protein creatinine ratio
  2. Values for categorical variables are given as number (percentage); values for continuous variables, as mean ± standard deviation or median [interquartile range]