Fig. 2

Renal function and autoimmune disease conditions in glomerular lesion (GL) models and GL-associated histological parameters in both GL and tubulointerstitial lesion (TIL) models. a Indices for renal function, including levels of serum blood urea nitrogen (sBUN) and serum creatinine (sCr) and urinary albumin creatinine ratios (uACRs), and for autoimmune disease conditions, namely serum levels of anti-dsDNA antibodies in Yaa mice and BXSB mice. b Indices for glomerular damage, namely glomerular (Glo.) size, cell number, and damage score, in model mice. c Indices for the number of infiltrating B220⁺B-cells, CD3⁺T-cells, and Iba1⁺macrophages and CD34⁺ capillaries in the glomeruli of model mice. Values = mean ± SE. ^#: Significant difference from the control in the same disease group, Mann–Whitney U test (p < 0.05). ^* Significant difference from the other groups, Kruskal-Wallis test followed by Scheffe’s method (^* p < 0.05, ^** p < 0.01). N = 4. a, b, c, and d denote BXSB/MpJ, BXSB/MpJ-Yaa, Control, and UUO kidney, respectively