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Table 3 Correlation of CD34+ tubulointerstitial capillaries with histopathological parameters of the tubulointerstitium in GL and TIL model mice

From: Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions

Parameters

Indices for tubulointerstitial histopathology

Ti. B220+B-cells/cortex

Ti. CD3+T-cells/cortex

Ti. Iba1+ macrophages/focus

Ti. αSMA+ myofibroblasts/focus

IL-1F6/IL-36α+ renal tubules/focus

CD34 + tubulointerstitial capillaries/focus

GL model

BXSB/MpJ

104.75 ± 16.70b#

59.75 ± 7.27b# bd*

12.43 ± 0.88b# bd*

0

1.25 ± 1.25d**

44.52 ± 2.76d**

BXSB/MpJ-Yaa

263 ± 85.90a# acd*

362.75 ± 133.06a# acd*

45.25 ± 8.91a# acd*

0

58.5 ± 24.38d**

44.51 ± 0.60d**

TIL model

Control kidney

25.75 ± 6.90d#

65.5 ± 6.75d# bd*

17.51 ± 1.31d# bd*

1463.06 ± 39.12d#

0

49.22 ± 3.12d**

UUO kidney

136 ± 6.14c# b*

707 ± 55.48c# ac** b*

70.73 ± 5.20c# ac** b*

14,579 ± 78.62c#

329.66 ± 11.01c# abc*

24.4 ± 1.86c# abc*

  1. Values = mean ± SE. #: Significant difference from the control in the same disease group, Mann–Whitney U test (p < 0.05). * Significant difference from the other groups, Kruskal-Wallis test followed by Scheffe’s method (* p < 0.05, ** p < 0.01). N = 4. Ti.: tubulointerstitial; GLs: glomerular lesions; TILs: tubulointerstitial lesions
  2. a, b, cand ddenotes BXSB/MpJ, BXSB/MpJ-Yaa, Control and UUO kidney, respectively