Parameters | Indices for tubulointerstitial histopathology | ||||||
---|---|---|---|---|---|---|---|
Ti. B220+B-cells/cortex | Ti. CD3+T-cells/cortex | Ti. Iba1+ macrophages/focus | Ti. αSMA+ myofibroblasts/focus | IL-1F6/IL-36α+ renal tubules/focus | CD34 + tubulointerstitial capillaries/focus | ||
GL model | BXSB/MpJ | 104.75 ± 16.70b# | 59.75 ± 7.27b# bd* | 12.43 ± 0.88b# bd* | 0 | 1.25 ± 1.25d** | 44.52 ± 2.76d** |
BXSB/MpJ-Yaa | 263 ± 85.90a# acd* | 362.75 ± 133.06a# acd* | 45.25 ± 8.91a# acd* | 0 | 58.5 ± 24.38d** | 44.51 ± 0.60d** | |
TIL model | Control kidney | 25.75 ± 6.90d# | 65.5 ± 6.75d# bd* | 17.51 ± 1.31d# bd* | 1463.06 ± 39.12d# | 0 | 49.22 ± 3.12d** |
UUO kidney | 136 ± 6.14c# b* | 707 ± 55.48c# ac** b* | 70.73 ± 5.20c# ac** b* | 14,579 ± 78.62c# | 329.66 ± 11.01c# abc* | 24.4 ± 1.86c# abc* |