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Fig. 1 | BMC Nephrology

Fig. 1

From: Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition

Fig. 1

Representative images of immunohistochemistry for E-cadherin (A and B), αSMA (C and D), and vimentin (E and F). E-cadherin staining was remarkable in tubules of CL kidneys (a), while it was significantly reduced in obstructed kidneys (b). Arrows in A and B indicate E-cadherin staining in tubules, and the asterisk indicates the interstitial cells. Immunohistochemistry for αSMA revealed that in CL kidneys (c), αSMA staining was found constitutively in vessels (asterisk) and within glomeruli (mesangial cells). In obstructed kidneys (d), the αSMA staining was robust in interstitium (arrow) and in tubules (arrowhead). Similar to αSMA, vimentin staining was found in vessels and glomeruli of the CL kidneys (e), while obstructed kidneys (F) presented additional positivity for vimentin in interstitial cells (arrow) and in tubules (arrowhead)

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