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Table 1 Baseline characteristics of 40 CKD subjects and 42 controls

From: Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD

Variables CKD (n = 40) Controls (n = 42)
Age (years) 62.9 ± 10.2 59.9 ± 9.8
Male (%) 28 (70.0) 26 (62.0)
BMI (kg/m2) 28.5 ± 5.3 27.6 ± 4.8
Race-Caucasian (%) 37 (95) 39 (95)
Diabetes mellitus (%) 17(42.5)** 4(9.5)
CVD (%) 12 (30.8)* 3 (7.1)
Hypertension (%) 38 (95)** 14 (33)
Hyperlipidemia (%) 26 (65) 13 (31)
Physically active (%) 18 (45)* 30 (73)
Systolic BP (mmHg) 131 ± 16 133 ± 16
Diastolic BP (mmHg) 75 ± 9 79 ± 10
eGFR (ml/min/1.73m2) 19.5 ± 6.7** 88.6 ± 12.9
uPCR (mg/mmol)a 84 (36–154)** 7 (5–9)
uACR (mg/mmol)a 43 (8.4–101.5)** 0.6 (0.5–0.9)
Serum Albumin (g/L) 38.5 ± 3.6** 41.5 ± 2.6
Hemoglobin (g/L) 120.7 ± 16.0** 145.0 ± 11.1
Urate (mmol/L) 0.43 ± 0.09** 0.33 ± 0.09
Serum bicarbonate (mmol/L) 23.4 ± 2.2** 27.1 ± 2.4
CRP (mg/L)a 1.0 (1.0–5.6) 1.0 (1.0–3.1)
Serum Corrected Calcium (mmol/L) 2.37 ± 0.14* 2.29 ± 0.07
Serum Phosphate (mmol/L) 1.40 ± 0.24** 1.13 ± 0.19
PTH (pmol/L)a 11.0 (7.2–22.0)** 3.5 (2.8–4.3)
25(OH) D (nmol/L) 89.8 ± 29.7* 77.6 ± 21.9
1,25(OH)2D (nmol/L) 83.9 ± 57.9** 145.4 ± 40.5
Soluble α-klotho (pg/mL)a 576.7 (473.6–704.3) 613.9 (497.3–933.8)
FGF23 (pg/mL)a 240.6 (141.9–1129.8)** 46.8 (33.1–56.3)
PWV (m/s)a 9.7 (7.6–11.7)* 8.1 (7.2–9.7)
AAC (%) 31 (83.8)* 17 (48.6)
AAC score 8 (3–14) 1 (0–5)
Medication Use
 Cholecalciferol (%) 8 (20.0) 4 (9.5)
 Activated vitamin D (%) 16 (38.1)** 0 (0)
 Calcium Supplements (%) 7 (17.5) 4 (9.5)
 ACEi/ARB (%) 28 (70.0)** 11 (26.2)
F/up duration (months) 12.4 ± 0.8 12.3 ± 0.7
  1. Data presented as mean ± standard deviation, numbers (%) or median (interquartile range); ausing non-parametric Wilcoxon signed rank sum test
  2. *denotes p < 0.05
  3. **denotes p ≤ 0.001 compared to controls
  4. Abbreviations: 1,25(OH) 2 D 1,25 dihydroxyvitamin D, 25(OH)D 25 hydroxyvitamin D, AAC abdominal aortic calcification, ACEi/ARB angiotensin converting enzyme inhibitor/angiotensin receptor blocker, BMI body mass index, BP blood pressure, CI confidence interval, CRP C-reactive protein, CVD cardiovascular disease, eGFR estimated glomerular filtration rate, FGF23 fibroblast growth factor 23, PTH parathyroid hormone, PWV pulse wave velocity, uACR urinary albumin-to-creatinine ratio, uPCR urinary protein-to-creatinine ratio