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Table 3 Clinical correlates of a) baseline abnormal PWV (≥10 m/s); b) baseline PWV and c) 12-month PWV in the entire study population

From: Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD

 

Unadjusted OR (95% CI)

p

Adjusted OR (95% CI)a

p

a) Abnormal PWV (≥10 m/s) at baseline

    

 Age (year)

1.12 (1.05–1.19)

0.001

1.14 (1.04–1.25)

0.004

 Diabetes

3.75 (1.33–10.56)

0.01

9.73 (1.37–69.0)

0.02

 Log FGF23 (pg/mL)

1.67 (1.14–2.43)

0.007

2.95 (1.04–8.34)

0.04

 Log PTH (pg/mL)

1.79 (1.03–3.08)

0.04

3.78 (1.31–10.9)

0.01

 eGFR(ml/min/1.73m2)

0.99 (0.97–1.00)

0.07

1.08 (1.03–1.15)

0.004

 

Unadjusted Coefficient (95% CI)

p

Adjusted Coefficient (95% CI)a

p

b) Baseline PWV

    

 Age (year)

0.02 (0.01–0.02)

<0.001

0.01 (0.01–0.02)

<0.001

 Hypertension

0.25 (0.14–0.37)

<0.001

0.24 (0.16–0.37)

<0.001

 eGFR(ml/min/1.73m2)

−0.002 (−0.003–0.0004)

0.06

0.006 (0.003–0.008)

<0.001

 Log PTH (pg/mL)

0.08 (0.02–0.2)

0.02

0.13 (0.06–0.20)

<0.001

 Log FGF23 (pg/mL)

0.06 (0.01–0.10)

0.01

0.05 (−0.003–0.11)

0.06

c) 12-month PWV

    

 Baseline PWV (m/s)

0.73 (0.56–0.90)

<0.001

0.49 (0.31–0.68)

<0.001

 Diabetes

0.18 (0.08–0.29)

0.001

0.16 (0.06–0.26)

0.002

 uPCR (mg/mmol)

0.0007 (0.0003–0.001)

0.002

0.0006 (0.0001–0.001)

0.008

 Log FGF23 (pg/mL)

0.06 (0.03–0.10)

0.001

0.04 (0.005–0.07)

0.03

  1. aAdjusted for age, diabetes, hypertension, eGFR, uPCR, corrected calcium, phosphate, PTH and FGF23
  2. Abbreviations: CI confidence interval, eGFR estimated glomerular filtration rate, FGF23 fibroblast growth factor 23, OR odds ratio, PTH parathyroid hormone level, PWV pulse wave velocity, UPCR urinary protein-to-creatinine ratio