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Table 3 Association analysis of genetic polymorphisms of the EDN1 gene and cardiovascular disease susceptibility in end-stage renal disease patients

From: Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

   Cardiovascular disease susceptibility   Recessive
rs number Genotype Cases (%) Control (%) OR (95% CI) p value q-value
rs3087459 CC 3 (3%) 3 (5.8%) 0.06 (0.01–0.69) 0.019 0.086
CA 26 (25.7%) 13 (25%) 1   
AA 72 (71.3%) 36 (69.2%) 1   
rs2248580 CC 8 (7.8%) 12 (21.8%) 0.10 (0.02–0.47) 0.001 0.013
CA 49 (48.0%) 22 (40.0%) 1   
AA 45 (44.1%) 21 (38.2%) 1   
rs2070699 GG 11 (11.7%) 16 (29.6%) 0.09 (0.02–0.38) <.001 0.003
GT 50 (53.2%) 22 (40.7%) 1   
TT 33 (35.1%) 16 (29.6%) 1   
rs5370 TT 5 (2.5%) 4 (10.0%) 0.30 (0.04–2.08) 0.216 0.388
TG 32 (40.0%) 20 (32.2%) 1   
GG 61 (57.5%) 28 (57.8%) 1   
rs4714384 TT 7 (7.2%) 14 (26.9%) 0.05 (0.01–0.23) <.001 <.001
TC 42 (43.3%) 17 (32.7%) 1   
CC 48 (49.5%) 21 (40.4%) 1   
  1. p values were adjusted for age, sex, smoking, diabetes, hypertension, pre-existing cardiovascular events, hemoglobin, albumin, ferritin, and the erythropoietin resistance index. p and q-values of <0.05 are shown in bold. q-values of <0.05 were considered statistically significant after correction for multiple testing. OR, odds ratio; CI, confidence interval