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Table 5 Association analysis of genetic polymorphisms of the EDN3 gene and cardiovascular disease susceptibility in end-stage renal disease patients

From: Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

   Cardiovascular disease susceptibility Recessive
rs number Genotype Cases (%) Control (%) OR (95% CI) p value q-value
rs742650 TT 0 (0%) 2 (3.9%) - 0.087 0.197
CT 20 (21.5%) 7 (13.7%) 1   
CC 73 (78.5%) 42 (82.4%) 1   
rs260741 AA 8 (8.4%) 4 (9.1%) 0.45 (0.08 ~ 2.44) 0.356 0.583
AG 31 (32.6%) 19 (43.2%) 1   
GG 56 (58.9%) 21 (47.7%) 1   
rs260740 GG 1 (1.0%) 0 (0%) - 0.708 0.796
GT 27 (26.0%) 16 (32.0%) 1   
TT 76 (73.1%) 34 (68.0%) 1   
rs197174 GG 1 (1.0%) 4 (7.7%) 0.12 (0.01 ~ 1.49) 0.074 0.197
GA 19 (18.4%) 9 (17.3%) 1   
AA 83 (39.0%) 39 (75.0%) 1   
rs197173 TT 9 (9.0%) 6 (11.1%) 1.67 (0.38 ~ 7.14) 0.497 0.662
GT 33 (33.0%) 18 (33.3%) 1   
GG 58 (58.0%) 30 (55.6%) 1   
rs6064764 CC 2 (1.9%) 1 (1.6%) 0.03 (0.01 ~ 1.59) 0.083 0.197
CT 24 (22.4%) 4 (6.3%) 1   
TT 81 (75.7%) 58 (92.1%) 1   
rs926632 CC 2 (1.9%) 3 (5.2%) 2.86 (0.97 ~ 8.33) 0.514 0.662
CT 19 (17.8%) 8 (13.8%) 1   
TT 86 (80.4%) 47 (81.0%) 1   
rs882345 GG 2 (1.9%) 2 (3.7%) 0.92 (0.05 ~ 16.67) 0.953 0.953
GA 14 (13.5%) 7 (13.0%) 1   
AA 88 (84.6%) 45 (83.3%) 1   
rs3026575 AA 1 (1.0%) 0 (0%) - 0.515 0.662
AG 7 (6.8%) 4 (7.1%) 1   
GG 95 (92.2%) 52 (92.9%) 1   
rs11570352 TT 3 (2.5%) 5 (7.0%) 0.20 (0.01 ~ 2.94) 0.216 0.388
TC 4 (3.4%) 1 (1.4%) 1   
CC 111 (94.1%) 65 (91.5%) 1   
  1. p values were adjusted for age, sex, smoking, diabetes, hypertension, pre-existing cardiovascular events, hemoglobin, albumin, ferritin, and the erythropoietin resistance index. q-values of <0.05 were considered statistically significant after correction for multiple testing. OR, odds ratio; CI, confidence interval