Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

BMC Nephrology

Table 5 Association analysis of genetic polymorphisms of the EDN3 gene and cardiovascular disease susceptibility in end-stage renal disease patients

		Cardiovascular disease susceptibility			Recessive
rs number	Genotype	Cases (%)	Control (%)	OR (95% CI)	p value	q-value
rs742650	TT	0 (0%)	2 (3.9%)	-	0.087	0.197
	CT	20 (21.5%)	7 (13.7%)	1
	CC	73 (78.5%)	42 (82.4%)	1
rs260741	AA	8 (8.4%)	4 (9.1%)	0.45 (0.08 ~ 2.44)	0.356	0.583
	AG	31 (32.6%)	19 (43.2%)	1
	GG	56 (58.9%)	21 (47.7%)	1
rs260740	GG	1 (1.0%)	0 (0%)	-	0.708	0.796
	GT	27 (26.0%)	16 (32.0%)	1
	TT	76 (73.1%)	34 (68.0%)	1
rs197174	GG	1 (1.0%)	4 (7.7%)	0.12 (0.01 ~ 1.49)	0.074	0.197
	GA	19 (18.4%)	9 (17.3%)	1
	AA	83 (39.0%)	39 (75.0%)	1
rs197173	TT	9 (9.0%)	6 (11.1%)	1.67 (0.38 ~ 7.14)	0.497	0.662
	GT	33 (33.0%)	18 (33.3%)	1
	GG	58 (58.0%)	30 (55.6%)	1
rs6064764	CC	2 (1.9%)	1 (1.6%)	0.03 (0.01 ~ 1.59)	0.083	0.197
	CT	24 (22.4%)	4 (6.3%)	1
	TT	81 (75.7%)	58 (92.1%)	1
rs926632	CC	2 (1.9%)	3 (5.2%)	2.86 (0.97 ~ 8.33)	0.514	0.662
	CT	19 (17.8%)	8 (13.8%)	1
	TT	86 (80.4%)	47 (81.0%)	1
rs882345	GG	2 (1.9%)	2 (3.7%)	0.92 (0.05 ~ 16.67)	0.953	0.953
	GA	14 (13.5%)	7 (13.0%)	1
	AA	88 (84.6%)	45 (83.3%)	1
rs3026575	AA	1 (1.0%)	0 (0%)	-	0.515	0.662
	AG	7 (6.8%)	4 (7.1%)	1
	GG	95 (92.2%)	52 (92.9%)	1
rs11570352	TT	3 (2.5%)	5 (7.0%)	0.20 (0.01 ~ 2.94)	0.216	0.388
	TC	4 (3.4%)	1 (1.4%)	1
	CC	111 (94.1%)	65 (91.5%)	1

p values were adjusted for age, sex, smoking, diabetes, hypertension, pre-existing cardiovascular events, hemoglobin, albumin, ferritin, and the erythropoietin resistance index. q-values of <0.05 were considered statistically significant after correction for multiple testing. OR, odds ratio; CI, confidence interval

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