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Fig. 3 | BMC Nephrology

Fig. 3

From: Identification of compound heterozygous patients with primary hyperoxaluria type 1: clinical evaluations and in silico investigations

Fig. 3

A) Sequence chromatograms showing the presence of c.26C > A and c.65A > G variants in Family F2. B) Multiple sequence alignment of alanine:glyoxylate aminotransferase (AGT) with different species showing the aminoacids at position 9 and 22. The concerned amino acids are boxed. C) Prediction of the effect of c.26C > A and c.65A > G variants on mRNA secondary structure; a) the wild-type AGT secondary structure; b) c.26C > A sowed no alteration on the RNA secondary structure; c) c.65 introduced several changes in the overall RNA secondary structure

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