Table 3 Treatments and outcomes
Parameters | Missing | Total (n = 56) | No-overcorrection (n = 45) | Overcorrection (n = 11) | p-value |
|---|---|---|---|---|---|
Treatment of hyponatremia | |||||
Hydration (0.9% saline) | 0 | 36 (64.3) | 30 (66.7) | 6 (54.5) | 0.452 |
Maintenance infusion (0.9% saline) | 0 | 32 (57.1) | 26 (57.8) | 6 (54.5) | 0.846 |
3% hypertonic saline | |||||
Bolus infusion | 0 | 1 (1.8) | 0 (0) | 1 (9.1) | 0.041 |
Continuous infusion | 0 | 16 (28.6) | 15 (33.3) | 1 (9.1) | 0.111 |
Diuretics | |||||
Loop diuretic (i.v.) | 0 | 4 (7.1) | 4 (8.9) | 0 (0.0) | 0.305 |
Tolvaptan (p.o.) | 0 | 4 (7.1) | 3 (6.7) | 1 (9.1) | 0.780 |
Intervention for overcorrection | |||||
D5W | 0 | 18 (32.1) | 12 (26.7) | 6 (54.5) | 0.076 |
Instructed to free water intake | 0 | 2 (3.6) | 1 (2.2) | 1 (9.1) | 0.271 |
DDAVP | 0 | 11 (19.6) | 5 (11.1) | 6 (54.5) | 0.001 |
Time from admission, hours | 0 | 8 (7–12) | 9 (8–9) | 8 (7–13) | 0.853 |
Outcomes | |||||
Osmotic demyelination | 0 | 0 (0.0) | 0 (0.0) | 0 (0.0) | NA |
Increase of serum Na, mEq/L | |||||
At 4 h | 5 | 2.0 (1.0–4.0) | 2.0 (0.0–3.0) | 6.5 (3.3–8.5) | 0.001 |
At 24 h | 0 | 8 (6–10) | 7 (5–9) | 12 (11–15) | <0.001 |
At 48 h | 5 | 14 (12–17) | 13 (11–15) | 19 (17–23) | <0.001 |
Early urine output, mL/h | 0 | 205 (114–386) | 183 (85–303) | 436 (196–998) | 0.005 |
Urine output at 24 h, mL | 0 | 2008 (1115–3101) | 1640 (855–3005) | 3725 (2229–4686) | 0.001 |
Urine output at 48 h, mL | 0 | 1930 (1416–3006) | 1875 (1315–2655) | 2695 (1723–3750) | 0.073 |