A low initial serum sodium level is associated with an increased risk of overcorrection in patients with chronic profound hyponatremia: a retrospective cohort analysis

Table 4 Impact of each variable on overcorrection

	Univariable		Multivariable model 1		Multivariable model 2
Parameters	OR (95% CI)	p-value	adjusted OR (95% CI)	p-value	adjusted OR (95% CI)	p-value
Age	0.97 (0.93–1.01)	0.108	0.98 (0.92–1.05)	0.537	–	–
Male	0.87 (0.22–3.30)	0.838	0.63 (1.00–3.56)	0.603	–	–
Primary Polydipsia	12.3 (2.02–102.00)	0.009	2.41 (0.09–60.20)	0.576	3.25 (0.16–73.04)	0.432
Serum Na	0.83 (0.71–0.94)	0.006	0.84 (0.70–0.98)	0.036	0.86 (0.73–0.99)	0.041
Serum Cr	1.12 (0.51–2.04)	0.722	1.61 (0.72–4.01)	0.218	–	–
Early urine output^a	1.41 (1.13–1.87)	0.006	1.30 (0.94–1.94)	0.149	1.26 (0.93–1.79)	0.163
3% hypertonic continuous infusion	0.20 (0.01–1.19)	0.142	0.54 (0.02–5.50)	0.629	–	–

CI confidence interval Cr creatinine, Na sodium, and OR odds ratio
Multivariable model 1 included all 7 variables shown in the Table. Multivariable model 2 included 3 variables that showed statistical significance on univariable analysis
^aOdds ratio per 100 mL increase

ISSN: 1471-2369