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Fig. 2 | BMC Nephrology

Fig. 2

From: Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation

Fig. 2

Uric acid treatment increased inflammation and fibrosis in kidney. a-b Reverse Transcriptase PCR showed inflammatory mediator (ICAM-1 and MCP-1) mRNA expression in UA group. c-e Sirius Red staining in 400× magnification and interstitial fibrosis area fraction quantification. It revealed higher quantification of area fraction in UA group and reduced in UAL7 and UAL14 groups. d-e Immunostaining of PDGFRβ as marker of fibroblast (400× magnification) to quantify fibroblast cell number. Fibroblast number/field was higher in UA group, and groups with alopurinol treatment (UAL7 and UAL14) had lower fibroblast number/field.*p < 0.05 VS control; ***p < 0.001 VS Control; #p < 0.05 VS UA14, ##p < 0.01 VS UA14

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BMC Nephrology

ISSN: 1471-2369

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