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Fig. 1 | BMC Nephrology

Fig. 1

From: Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1

Fig. 1

Caveolar proteins are normally not expressed in proximal tubules, but are induced in atrophic tubular segments. Immunohistochemical stainings of human renal tissue showing the distribution of caveolar proteins. Expression of caveolin-1/CAV1 and caveolin-2/CAV2 (a through d) was observed in the PECs, endothelial cells and smooth muscle cells (SMC). No caveolin-3/CAV3 staining could be detected (e and f). PTRF/CAVIN1 staining was observed in PECs and SMCs of large arteries (g and h). PECs and endothelial cells stained positive for SDPR/CAVIN2 (i and j). PRKCDBP/CAVIN3 staining was observed in PECs, and SMCs of arteries, (k and l) whereas MURC/CAVIN4 staining could not be detected (data not shown). In proximal tubules undergoing atrophy due to normal kidney ageing, tubular cells were positive for caveolin-1/CAV1, caveolin-2/CAV2, SDPR/CAVIN2 and PRKCDBP/CAVIN3 (m-p). G - glomerulus, PT - proximal tubules, IC - inflammatory cells, PEC - parietal epithelial cells. Inserted squares mark areas magnified in the following image

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BMC Nephrology

ISSN: 1471-2369

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