Fig. 4
Hypoxia has an inhibitory effect on some of the caveolin and cavin levels. To investigate if hypoxia may induce expression of caveolar proteins, cultured tubular cells were exposed to hypoxia (1% O2). The mRNA (a) and protein levels (b) of caveolins (caveolin-1/CAV1, caveolin-2/CAV2) and cavins (PTRF/CAVIN1, SDPR/CAVIN2, PRKCDBP/CAVIN3) in primary kidney epithelial cells after normoxic (white bars) or hypoxic (black bars) culture for 24 h are shown. Hypoxia resulted in statistically significant decrease of caveolin-2/CAV2 and SDPR/CAVIN2 expression, whereas the other caveolar proteins were unaltered *(p < 0.05)