Table 1 Animal data and laboratory findings in the study groups
Control | Ade | Ade + S | Ade + C | Ade + SC | |
|---|---|---|---|---|---|
Number of animals | 12 | 20 | 16 | 16 | 16 |
Body weight (g) | |||||
week 0 | 406 ± 8 | 409 ± 5 | 409 ± 5 | 409 ± 5 | 409 ± 5 |
week 12 | 450 ± 11 | 339 ± 6* | 341 ± 6* | 340 ± 7* | 359 ± 8* |
Chow intake at week 10 (g/24 h) | 20.3 ± 1.0 | 13.9 ± 0.3* | 16.5 ± 0.5*† | 15.1 ± 0.7* | 14.8 ± 0.8* |
Systolic blood pressure (mmHg) | |||||
week 0 | 139 ± 1 | 138 ± 1 | 139 ± 1 | 138 ± 1 | 139 ± 1 |
week 9 | 137 ± 2 | 138 ± 1 | 130 ± 2† | 138 ± 1‡ | 129 ± 2*† |
Drinking volume (ml/24 h) | 31.0 ± 1.9 | 87.5 ± 2.9* | 88.1 ± 1.8* | 83.5 ± 3.5* | 81.2 ± 2.4* |
Urine volume (ml/24 h) | 20.0 ± 2.3 | 73.9 ± 2.2* | 82.7 ± 2.7*‡ | 69.1 ± 3.8*‡ | 54.7 ± 2.5*† |
24-h creatinine clearance (μl/min/kg)a | 379 ± 23 | 82 ± 6* | 119 ± 8*† | 96 ± 11* | 122 ± 13*† |
Final plasma | |||||
Sodium (mmol/l) | 135.1 ± 0.7 | 138.3 ± 0.5* | 141.5 ± 0.6*† | 140.1 ± 0.5* | 140.7 ± 0.5*† |
Potassium (mmol/l) | 3.63 ± 0.09 | 4.34 ± 0.07* | 4.22 ± 0.08* | 4.19 ± 0.12* | 4.05 ± 0.07* |
Cholesterol (mmol/l) | 1.45 ± 0.05 | 2.32 ± 0.10* | 1.78 ± 0.09† | 1.99 ± 0.10*‡ | 1.61 ± 0.05† |
HDL (mmol/l) | 0.60 ± 0.02 | 0.91 ± 0.04* | 0.70 ± 0.02† | 0.82 ± 0.04* | 0.69 ± 0.02*† |
Trigly (mmol/l) | 1.06 ± 0.14 | 1.14 ± 0.10 | 0.86 ± 0.10 | 0.98 ± 0.08‡ | 0.68 ± 0.04† |
Non-HDL (mmol/l) | 0.86 ± 0.04 | 1.41 ± 0.07* | 1.08 ± 0.08† | 1.17 ± 0.07*‡ | 0.92 ± 0.04† |
Proteins (g/l) | 53.4 ± 1.0 | 51.9 ± 0.8 | 52.8 ± 1.2 | 51.1 ± 1.5 | 51.9 ± 0.9 |