Table 4 Median serum creatinine (μmol/L), delta serum creatinine improvement and the percentage of patients with decreased serum creatinine at two week post biopsy
From: The increasing rates of acute interstitial nephritis in Australia: a single centre case series
N = 28 | Median SCr at 2 weeks (IQR) | Decrease in SCr at 2 weeks (IQR) | Percentage patient with decreased SCr at 2 weeks (%) |
|---|---|---|---|
All patients (28) | 136 (112–197) | 93 (14–158) | 79 |
Gender | |||
Male (14) | 133 (112–185) | 123 (87–170) | 86 |
Female (14) | 141 (119–119) | 58 (4–104) | 71 |
P | 0.66 | 0.18 | |
Comorbidities | |||
Ischaemic Heart Disease (5) | 193 (159–209) | 124 (68–152) | 100 |
Hypertension (10) | 129 (113–163) | 110 (6–209) | 70 |
Dyslipidaemia (7) | 193 (133–265) | 88 (47–138) | 86 |
Diabetes Mellitus (type 1 or 2) (9) | 170 (159–290) | 88 (30–124) | 78 |
Autoimmune conditions (6) | 129 (113–141) | 44 (113–141) | 67 |
PPI use (10) | 173 (115–244) | 91 (51–170) | 90 |
Cancer (9) | 129 (112–193) | 90 (3–176) | 78 |
Mental and Behavioural condition (5) | 208 (142–290) | 96 (68–188) | 100 |
Presumed Cause of AIN | |||
Unknown (9) | 170 (114–248) | 90 (−3–146) | 67 |
Antibiotic (5) | 127 (112–131) | 176 (68–303) | 100 |
Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) (3) | 139 (128–149) | 88 (43–105) | 67 |
PPI/H2 antagonist (4) | 184 (129–245) | 72 (39–130) | 100 |
Immune mediated diseases (6) | 119 (99–136) | 90 (16–104) | 67 |
Other (1) | 314 | 241 | 100 |
P | 0.29 | 0.43 | |
Treatment | |||
Steroid therapy (16) | 135 (110–159) | 189 (14–158) | 81 |
No treatment given (12) | 154 (113–218) | 102 (34–170) | 75 |
P | 0.59 | 0.58 | |
Co-existent Disease on Biopsy | |||
Hypertensive Nephrosclerosis (3) | 157 (143–176) | 124 (64–214) | 100 |
Diabetic Nephropathy (3) | 170 (116–231) | –3 (−4–21) | 33% |
No co-existent disease (22) | 134 (112–196) | 96 (36–170) | 82 |
P | 0.79 | 0.15 | |
AKIN Severity (n = 13) | |||
1 (5) | 159 (94–170) | 3 (−6–18) | 60 |
2 (3) | 119 (115–204) | 119 (115–204) | 67 |
3 (5) | 112 (102–127) | 228 (176–303) | 100 |
P | 0.65 | 0.01 | |
Renal Replacment Therapy | N (%) | ||
RRT at two weeks | 2 (5) | ||
RRT at 3 months or later | 3 (7.5) | ||