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Table 3 Multivariable analyses investigating the association between delta chloride (Δ Cl) from admission to 72 h post-admission and 1) any AKI at 72 h and 2) moderate/severe AKI at 72 h

From: Effect of hyperchloremia on acute kidney injury in critically ill septic patients: a retrospective cohort study

Variable Any AKI
Hyperchloremic Subgroup
Moderate/Severe AKI
Hyperchloremic Subgroup
Odds Ratio
Multivariable
P-value Odds Ratio
Multivariable
P-value
ΔCl
per mEq/L increase
1.04
(0.97–1.11)
0.2652 1.03
(0.93–1.14)
0.6164
Male 1.49
(0.60–3.70)
0.3948 6.38
(1.16–34.99)
0.0329
Diabetes 0.55
(0.20–1.50)
0.2449 0.88
(0.21–3.73)
0.8645
Hypertension 0.60
(0.26–1.36)
0.2196 0.55
(0.15–1.95)
0.3545
Heart failure 7.06
(1.33–37.52)
0.0219 2.54
(0.15–43.62)
0.5205
Diuretic 3.35
(1.26–8.91)
0.0156 3.61
(0.74–17.60)
0.1118
Statin 0.51
(0.20–1.30)
0.1564 1.12
(0.26–4.83)
0.8795
Oliguria 6.09
(1.66–22.39)
0.0066 33.05
(4.89–223.45)
0.0003
CFB 72 h
per 100 ml increase
1.00
(1.00–1.01)
0.4866 1.01
(1.00–1.02)
0.1821
Pressor or inotrope 1.37
(0.51–3.69)
0.5277 1.66
(0.35–8.01)
0.5255
Mechanical ventilation 1.10
(0.36–3.32)
0.8734 1.46
(0.26–8.37)
0.6703
Base Deficit
per mEq/L increase
1.05
(0.96–1.15)
0.2777 1.12
(0.96–1.30)
0.1411
SOFA score
per unit increase
1.09
(0.95–1.25)
0.2340 0.98
(0.80–1.20)
0.8472
  1. CFB = cumulative fluid balance; oliguria defined as urine output less than 500 ml in 24 h; anemia = admission hematocrit <39% for men and <36% for women;; SOFA = Sequential Organ Failure Assessment; Any AKI, KDIGO Stage ≥1 SCr-based; Moderate/severe AKI, KDIGO Stage ≥2 SCr-based
  2. The two multivariate models are investigating the association between delta chloride at 72 h (ΔCl = Cl72 – Cl0) and 1) any AKI at 72 h and 2) moderate/severe AKI at 72 h in the hyperchloremic subgroup. Both models are adjusted for variables with P-value <0.25 on univariate analysis reported in Table 2