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Table 1 Clinicopathological findings of patients with ANCA-associated renal vasculitis in each anaemia severity group

From: Anaemia is an essential complication of ANCA-associated renal vasculitis: a single center cohort study

Variable All patients Min Hb <7.5 Min Hb ≥7.5 P Value
Patient number 45 24 21  
Gender male:female 20:25 12:12 8:13 0.42
Age (years) 71 ± 7.8 (47–82) 72 ± 7.0 (54–82) 70 ± 8.7 (47–82) 0.36
Birmingham vasculitis activity score 20 (12–39) 19 (12–36) 20 (12–39) 0.58
Haemoglobin on admission (g/dL) 9.0 ± 1.6 8.1 ± 1.1 10.1 ± 1.3 <0.001
Minimum haemoglobin (g/dL) 7.5 ± 1.3 6.5 ± 0.6 8.7 ± 0.9 <0.001
MCV (fL) 90 ± 6.2 88 ± 6.8 91 ± 5.1 0.18
MCH (pg) 29.5 ± 2.4 29.1 ± 2.6 30.0 ± 2.2 0.21
MCHC (%) 33.0 ± 1.2 32.9 ± 0.9 33.0 ± 1.3 0.76
Reticulocyte count (×104/μL) 4.65 ± 2.50 4.23 ± 2.47 5.09 ± 2.54 0.35
Serum erythropoietin (mIU/mL) 15.1 (5.8–105) 17.5 (5.8–105) 14.5 (11–36.6) 0.43
Transferrin saturation (%) 14.7 (4.2–80.2) 12.8 (4.2–80.2) 17.5 (9.7–54.5) 0.18
Serum ferritin (ng/mL) 322 (46.9–2231) 382 (46.9–1839) 291 (94.9–2231) 0.21
Serum c-reactive protein (mg/dL) 6.8 (0.03–24.5) 7.9 (0.43–24.5) 5.0 (0.03–17.3) 0.09
Serum hepcidin-25 (ng/mL) 71.5 (10.5–463) 74.9 (45.9–463) 37 (10.5–363) 0.28
Serum albumin (g/dL) 2.6 ± 0.8 2.3 ± 0.6 2.9 ± 0.8 0.004
Serum creatinine on admission (mg/dL) 2.5 (1.0–10.8 2.9 (1.0–10.8) 2.3 (1.0–6.3) 0.06
Maximum serum creatinine (mg/dL) 3.2 (1.0–11.7) 4.4 (1.1–11.7) 2.4 (1.0–7.2) 0.01
eGFR on admission (mL/min/1.73 m2) 19.5 (4.2–54.2) 13.8 (4.2–44.6) 21.6 (7.0–54.2) 0.09
Minimum eGFR (mL/min/1.73 m2) 15.3 (3.9–54.2) 8.9 (3.9–39.2) 19.0 (4.8–54.2) 0.01
Blood urea nitrogen (mg/dL) 34.5 (13–101) 36.9 (13–101) 30.9 (18.3–62) 0.09
Serum cystatin c (mg/L) 2.8 ± 0.9 3.2 ± 0.9 2.2 ± 0.6 0.02
Number of renal biopsy, n (%) 33 (73) 13 (54) 20 (95) 0.00
Area of tubulointerstitial damage (%) 55 ± 21 65 ± 18 48 ± 20 0.048
  1. Values are shown as the numbers of patients, the median (range) or the mean ± SD. Abbreviations: Min Hb Minimum haemoglobin, MCV Mean corpuscular volume, MCH Mean corpuscular haemoglobin, MCHC Mean corpuscular haemoglobin concentration, eGFR Estimated glomerular filtration rate