From: Hyperbaric oxygen treatment and nephrotoxicity induced by gentamicin in rats
Control group (n = 6) | Group 1 (n = 10) | Group 2 (n = 10) | Group 3 (n = 8) | P-value | |
---|---|---|---|---|---|
Weight (gr) Day1 (±SD) | 292.2 ± 12.16 | 289 ± 8.93 (279-304) | 294.3 ± 15.37 (267-315) | 299.9 ± 7.50 (289-313) | 0.11 |
Weight(gr) Day 6 (±SD) | 310.3 ± 10.31 | 280.8 ± 11.25 (262-297) | 292.2 ± 13.39 (271-318) | 287.04 ± 7.4 (280-300) | 0.89 |
Urea (mg/dl) (±SD) | 42 ± 2 | 218.96 ± 95.65 (93-329.6) | 202.35 ± 66.08 (82.7-311.5) | 229.18 ± 48.05 (170.5-298.1) | 0.741 |
Creatinine (mg/dl) (±SD) | 0.41 ± 0.02 | 3.43 ± 1.517 (1.58-5.58) | 3.16 ± 1.162 (1.21-4.46) | 3.5 ± 0.66 (2.58-4.63) | 0.813 |
Sodium (mmol/l) (±SD) | 142 ± 1.5 | 141.4 ± 3.23 (136-146) | 140.5 ± 3.44 (132-144) | 140.88 ± 2.41 (136-144) | 0.811 |
Potassium (mmol/l) (±SD) | 5.5 ± 0.3 | 4.62 ± 0.39 (4.06-5.8) | 4.78 ± 0.36 (4.17-5.4) | 4.83 ± 0.49 (4.42-5.93) | 0.519 |
Chloride (mmol/l) (±SD) | 94.2 ± 3.7 | 94.7 ± 3.88 (88-100) | 95.4 ± 4.9 (85-103) | 95.75 ± 1.98 (93-99) | 0.842 |
Magnesium (mg/dl) (±SD) | 4.13 ± 0.33 | 5.03 ± 0.64 (3.9-6.09) | 5.3 ± 1.21 (3.58-7.23) | 5.34 ± 0.52 (4.57-6.12) | 0.701 |
Calcium (mg/dl) (±SD) | 11.8 ± 0.1 | 11.95 ± 7.44 (11.2-13.8) | 12.8 ± 0.87 (11.8-14.9) | 12.06 ± 0.47 (11.2-12.6) | 0.034 |
Gentamicin levels (μg/ml) (±SD) | 0 | 24.24 ± 31.06 (5.2-88.4) | 24.03 ± 20.15 (3.1-61.5) | 30.62 ± 17.71 (9.9-64.9) | 0.806 |