Skip to main content
Fig. 1 | BMC Nephrology

Fig. 1

From: IgA nephropathy featuring massive wire loop-like deposits in two patients with alcoholic cirrhosis

Fig. 1

a: Case 1: Light microscopy (LM) of the first renal biopsy specimen shows massive subendothelial wire loop-like deposits of amorphous material in the glomerular basement membrane (GBM) and similar deposits the mesangium. b: Immunofluorescence (IF) is positive for IgA(IgA1 > IgA2) and C3, predominantly in the mesangium and GBM. c: Electron microscopy (EM) shows huge subendothelial electron-dense deposits (EDD) without an organized internal structure in the GBM and similar deposits in the mesangium. d: LM of the second renal biopsy specimen demonstrates marked improvement of the glomerular changes. e: IF shows weaker staining for IgA and C3 compared to that seen in the first biopsy. f: EM reveals disappearance of the massive EDD

Back to article page