Table 1 Clinical characteristics of ABO-incompatible accommodation, ABO-compatible stable, and ABO-incompatible rejection kidney transplantation groups
Parameters | ABO-incompatible accommodation group (n = 16) | ABO-compatible stable group (n = 6) | ABO-incompatible rejection group (n = 6) | P-valuea |
|---|---|---|---|---|
Age at transplantation (yr) | 40.8 ± 13.8 | 44.2 ± 11.7 | 49.2 ± 11.1 | 0.406 |
Male sex (%) | 9 (56.2%) | 2 (33.3%) | 4 (66.7%) | 0.485 |
Body mass index (kg/m2) | 21.6 ± 2.3 | 20.5 ± 3.0 | 22.9 ± 1.9 | 0.242 |
Diabetes (%) | 2 (12.5%) | 0 (0.0%) | 1 (16.7%) | 0.608 |
Hypertension (%) | 13 (81.2%) | 6 (100.0%) | 6 (100.0%) | 0.284 |
ABO incompatibility (%) | <0.001 | |||
- A to B | 0 (0.0%) | 1 (16.7%) | ||
- A to O | 4 (25.0%) | 1 (16.7%) | ||
- AB to A | 1 (6.2%) | 0 (0.0%) | ||
- AB to B | 3 (18.8%) | 0 (0.0%) | ||
- B to A | 5 (31.2%) | 1 (16.7%) | ||
- B to O | 3 (18.8%) | 3 (50.0%) | ||
Pre-transplant dialysis (%) | 0.122 | |||
- Hemodialysis | 12 (75.0%) | 4 (66.7%) | 3 (50.0%) | |
- Peritoneal dialysis | 0 (0.0%) | 2 (33.3%) | 2 (33.3%) | |
- Preemptive | 4 (25.0%) | 0 (0.0%) | 1 (16.7%) | |
Duration of dialysis (mo) | 30.7 ± 58.1 | 24.2 ± 52.9 | 8.5 ± 12.5 | 0.667 |
Cause of ESRD (%) | 0.590 | |||
- Diabetes | 2 (12.5%) | 0 (0.0%) | 1 (16.7%) | |
- Glomerulonephritis | 10 (62.5%) | 4 (66.7%) | 3 (50.0%) | |
- Hypertension | 0 (0.0%) | 1 (16.7%) | 0 (0.0%) | |
- Polycystic disease | 3 (18.8%) | 0 (0.0%) | 1 (16.7%) | |
- Unknown | 1 (6.2%) | 1 (16.7%) | 1 (16.7%) | |
Serum creatinine at discharge (mg/dL) | 1.1 ± 0.2 | 0.9 ± 0.1 | 1.5 ± 1.3 | 0.186 |
Estimated GFR at discharge (mL/min) | 86.8 ± 24.5 | 95.9 ± 13.9 | 74.2 ± 32.8 | 0.328 |
Serum creatinine at 3 years after transplantation (mg/dL) | 1.7 ± 1.7 | 1.1 ± 0.1 | 1.2 ± 0.5 | 0.651 |
Estimated GFR at 3 years after transplantation (mL/min) | 54.6 ± 19.4 | 57.0 ± 7.2 | 59.1 ± 15.7 | 0.878 |
Calcineurin inhibitor (%) | 0.149 | |||
- Tacrolimus | 16 (100.0%) | 5 (83.3%) | 6 (100.0%) | |
- Cyclosporine | 0 (0.0%) | 1 (16.7%) | 0 (0.0%) | |
Trough level of tacrolimus at discharge (ng/mL) | 9.3 ± 2.3 | 9.1 ± 1.0 | 10.8 ± 3.0 | 0.382 |
HLA mismatch (number) | 2.9 ± 1.3 | 5.2 ± 0.8 | 2.8 ± 1.2 | 0.001 |
HBsAg positivity (%) | 1 (6.2%) | 1 (16.7%) | 0 (0.0%) | 0.522 |
Anti-HCV positivity (%) | 0 (0.0%) | 1 (16.7%) | 0 (0.0%) | 0.149 |
Donor | ||||
- Age at transplantation (yr) | 43.9 ± 10.9 | 43.5 ± 7.5 | 40.3 ± 14.0 | 0.795 |
- Male sex (%) | 7 (43.8%) | 5 (83.3%) | 4 (66.7%) | 0.215 |
- Body mass index (kg/m2) | 23.3 ± 2.9 | 23.3 ± 2.0 | 24.8 ± 2.2 | 0.437 |
- Serum creatinine (mg/dL) | 0.8 ± 0.2 | 0.8 ± 0.1 | 0.9 ± 0.2 | 0.272 |